Development and Evaluation of Proliposomes-Based Drug Delivery Systems (Paperback)

The present investigation aimed at formulation, and evaluation of vesicular drug carrier system liquid crystalline proliposomes for transdermal delivery of antifungal agent, griseofulvin. Liquid crystalline proliposomal gel (LCPG) formulations of griseofulvin were prepared, and characterized for vesicles shape, size, entrapment efficiency, and drug permeation across pig ear skin. The effects of different formulation variables (type of alcohol, type and concentration of surfactant) on transdermal permeability profile were assessed. The optimized LCPG formulation showed enhanced In Vitro skin permeation flux of 10.705 0.052 ug/cm2/hr as compared to 0.028 0.02 ug/cm2/hr for plain drug solution in water. Results indicated that the optimized proliposomal formulation of griseofulvin had better skin permeation potential than plain drug solution in water."

General

Imprint:	Lap Lambert Academic Publishing
Country of origin:	Germany
Release date:	June 2012
First published:	June 2012
Authors:	Sandeep Gupta • Dheeraj Ahirwar • Aditya Nath Pandey
Dimensions:	229 x 152 x 4mm (L x W x T)
Format:	Paperback - Trade
Pages:	64
ISBN-13:	978-3-659-16098-1
Categories:	Books > Medicine > Other branches of medicine > Pharmacology > General
LSN:	3-659-16098-9
Barcode:	9783659160981

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