The latest data on the pathogenesis of ulcer disease is presented
in this text, with the emphasis that an understanding of the
pathogenesis and etiology of ulcer diseases represents the most
rational approach to pharmacology - the prevention and treatment of
ulcer disease. Early and late biochemical and functional changes,
morphologic stages of the injury and healing phases, as well as
vascular factors in ulceration are highlighted. In addition, new
pathogenetic elements on neuroendocrine and other endogenous
modulators and circadian rhythms in ulcerogenesis are covered. The
section on new pharmacology consists of several chapters presenting
new animal models of gastric, small intestinal and colonic ulcers
because in vivo models represent the basis to test and accurately
detect new antiulcer drugs. A large series of chapters cover new
drugs for ulcer prevention and treatment. This book is
indispensible to investigators in basic and applied research,
academic and industrial pharmacologists and clinicians in
gastroenterology.
General
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