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Principles and Practice of Systematic Reviews and Meta-Analysis (Hardcover, 1st ed. 2021)
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Principles and Practice of Systematic Reviews and Meta-Analysis (Hardcover, 1st ed. 2021)
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Evidence based medicine is at the core of modern medicine. It
involves the integration of individual clinical expertise with the
best available clinical evidence from systematic research and
patient's values and expectations. Systematic reviews offer a
summary of the best available evidence. They are the most reliable
and comprehensive statement about what works. Written by clinical
academics from Australia, UK, USA, and Switzerland, this
contributed volume introduces the readers to the principles and
practice of systematic reviews and meta-analysis. It covers the
various steps involved in systematic reviews including development
of a focused question and the strategy for conducting a
comprehensive literature search, identifying studies addressing the
underlying question, assessment of heterogeneity and the risk of
bias in the included studies, data extraction, and the approach to
meta-analysis. Crucial issues such as selecting the model for
meta-analysis, generating and interpreting forest plots, assessing
the risk of publication bias, cautions in the interpretation of
subgroup and sensitivity analyses, rating certainty of the evidence
using GRADE guideline, and standardized reporting of meta-analysis
(PRISMA) are covered in detail. Every attempt is made to keep the
narrative simple and clear. Mathematical formulae are avoided as
much as possible. While the focus of this book is on systematic
reviews and meta-analyses of randomised controlled trials (RCTs),
the gold standard of clinical research, the essentials of
systematic reviews of non-RCTs, diagnostic test accuracy studies,
animal studies, individual participant data meta-analysis, and
network meta-analysis are also covered. Readers from all faculties
of medicine will enjoy this comprehensive and reader friendly book
to understand the principles and practice of systematic reviews and
meta-analysis for guiding their clinical practice and research.
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