The Histone Code and Beyond - New Approaches to Cancer Therapy (Paperback, 2006 ed.)

Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.

General

Imprint:	Springer-Verlag
Country of origin:	Germany
Series:	Ernst Schering Foundation Symposium Proceedings, 57
Release date:	November 2014
First published:	2006
Editors:	Shelley L. Berger • O. Nakanishi, • Bernhard Haendler
Dimensions:	235 x 155 x 12mm (L x W x T)
Format:	Paperback
Pages:	215
Edition:	2006 ed.
ISBN-13:	978-3-642-42175-4
Categories:	Books > Science & Mathematics > Biology, life sciences > Biochemistry > General Books > Science & Mathematics > Biology, life sciences > Cellular biology > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
LSN:	3-642-42175-X
Barcode:	9783642421754

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