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Books > Medicine > Pre-clinical medicine: basic sciences > Physiology
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Bile Acids and Their Receptors (Hardcover, 1st ed. 2019)
Loot Price: R4,519
Discovery Miles 45 190
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Bile Acids and Their Receptors (Hardcover, 1st ed. 2019)
Series: Handbook of Experimental Pharmacology, 256
Expected to ship within 10 - 15 working days
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This book focusses on the latest results related to the field of
bile acids as signaling molecules and describes how these receptors
have become a major pharmacological target. It covers all major
areas of research in this field, from genetics, chemistry, in
silico modeling, molecular biology to clinical applications,
offering a cross-country view of the functional role of bile acids
as signaling molecules, virtually acting on all major areas of
metabolism. While FXR and GPBAR1 are essential bile acid sensors
that integrate the de novo bile acid synthesis with intestinal
microbiota and liver metabolism, in a broader sense, BARs play a
pathogenic role in the development of common human alignments
including liver, intestinal and metabolic disorders, such as
steatosis (NAFLD) and steato-hepatitis (NASH), diabetes, obesity
and atherosclerosis.
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