The subject of this volume is a comprehensive examination of the
biochemistry and biology of all classes of known PAS proteins, with
the intention that readers will find insight into their own work
and ideas from study of the multitude of PAS protein functions. PAS
proteins control numerous physiological and developmental events,
and span phylogeny from bacteria to man. Bacterial and plant PAS
proteins act as sensors of environmental stimuli, including light,
oxygen, and energy status.
Not surprising, given these roles, there is intense
investigation of the roles of bHLH-PAS proteins in issues of human
health including: (1) cancer induction, (2) cancer growth and
vascularity, (3) birth defects, including Down syndrome, (4)
appetite control and obesity, (5) sleep rhythm disorders, and (6)
mental health disorders such as social interactions and
learning.
PAS proteins encompass many fields of biology, and scientists
who work in these fields (circadian rhythms, oxygen regulation,
toxin metabolism, bacterial sensors, and development) are an
audience, particularly those who actively work on PAS proteins and
researchers interested in transcriptional control, signal
transduction, and evolution.
General
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