The onset of cancer presents one of the most fundamental
problems in modern biology. In "Dynamics of Cancer," Steven Frank
produces the first comprehensive analysis of how particular genetic
and environmental causes influence the age of onset.
The book provides a unique conceptual and historical framework
for understanding the causes of cancer and other diseases that
increase with age. Using a novel quantitative framework of
reliability and multistage breakdown, Frank unifies molecular,
demographic, and evolutionary levels of analysis. He interprets a
wide variety of observations on the age of cancer onset, the
genetic and environmental causes of disease, and the organization
of tissues with regard to stem cell biology and somatic mutation.
Frank uses new quantitative methods to tackle some of the classic
problems in cancer biology and aging: how the rate of increase in
the incidence of lung cancer declines after individuals quit
smoking, the distinction between the dosage of a chemical
carcinogen and the time of exposure, and the role of inherited
genetic variation in familial patterns of cancer.
This is the only book that presents a full analysis of the age
of cancer onset. It is a superb teaching tool and a rich source of
ideas for new and experienced researchers. For cancer biologists,
population geneticists, evolutionary biologists, and demographers
interested in aging, this book provides new insight into disease
progression, the inheritance of predisposition to disease, and the
evolutionary processes that have shaped organismal design.
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