With an estimated 1.3 million new cases and causing more than
20,000 deaths every year, Leishmaniasis continues to be a menace in
countries across the globe. The absence of an anti-Leishmania
vaccine, the toxicity of current anti-parasite drugs, coupled with
the rapid emergence of drug resistant Leishmania strains remain
significant challenges for disease control. This has spurred a
plethora of research initiatives into the parasite biology,
parasite-host interaction, mechanisms of disease pathogenesis, drug
development and molecular mechanism of drug resistance. Insights
obtained from various such studies are essential for the
development of novel anti-Leishmania treatment strategies. In this
timely book respected Leismania experts distil the important
current research highlighting the most insightful discoveries in
the field. Topics covered include: modulation of host miRNA; heat
shock proteins; Iron in the Leishmania-macrophage interaction;
oxidative and nitrosative stress response; cell death; strategies
for immune evasion; STAT signalling; parasite modulation of
toll-like receptors in macrophages; T cells in Leishmania
infection; vaccine biology; inhibitors of Leishmania DNA
topoisomerases; and mechanism of drug resistance in visceral
Leishmaniasis. An essential text for everyone in the Leishmania
community and recommended for researchers working in related
fields.
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