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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Biochemical immunology
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Lymphocyte Activation and Immune Regulation IX - Homeostasis and Lymphocyte Traffic (Hardcover, 2002 ed.)
Loot Price: R3,040
Discovery Miles 30 400
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Lymphocyte Activation and Immune Regulation IX - Homeostasis and Lymphocyte Traffic (Hardcover, 2002 ed.)
Series: Advances in Experimental Medicine and Biology, 512
Expected to ship within 10 - 15 working days
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During the past five years major progress has been made in
understanding the basic mechanisms of lymphocyte homeostasis and in
the developmental relationship between different memory T subsets
and their traffic patterns and functional significance. This volume
highlights the current concepts of lymphocyte development, factors
regulating lymphocyte trafficking and development, and specialized
characteristics and functional properties of naive and memory
subsets. This volume is divided into three sections. Section I
deals with factors that regulate the development and maturation of
T cells and B cells and lymphocyte traffic. The significance of
C-kit, Bcl-6, IL-7, and Vav in the development of T and B
lymphocytes is discussed. A role of lymphotoxins and VAP-I in
trafficking of leucocytes is reviewed. Finally, the trafficking and
homing characteristics of T cell and B cell subsets, and the
regulation of these processes during the immune response, is
presented. Section II discusses various aspects of naive and memory
T cell biology, including clonal expansion, reprogramming of genes
including those encoding cytokines and cytotoxic granules, changes
in the expression of cell surface proteins involved in cell-cell
adhesion, homing of naive and memory T cells, the role of MHC and
cytokines in the maintenance of naive and memory T cells, and the
characterization and differentiation of virus-specific memory T
cell heterogeneity in mice and humans. Novel methods of
visualization of immune cells and immune systems are reviewed in
Section III. This includes tracking of dendritic cells in vivo,
monitoring arterial smooth muscle-specific T cells in the inflamed
vasculature, imaging of molecular migrations in immune synapses,
and visualization of various immune cells in intact lymphoid
tissues by two photon confocal imaging. This volume should be of
interest to immunologists, molecular biologists, microbiologists,
pathologists, academic physicians, cell bio
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