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Pharmacology in Drug Discovery and Development - Understanding Drug Response (Paperback, 2nd edition)
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Pharmacology in Drug Discovery and Development - Understanding Drug Response (Paperback, 2nd edition)
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Pharmacology in Drug Discovery and Development: Understanding Drug
Response, Second Edition, is an introductory resource illustrating
how pharmacology can be used to furnish the tools necessary to
analyze different drug behavior and trace this behavior to its root
cause or molecular mechanism of action. The concepts discussed in
this book allow for the application of more predictive
pharmacological procedures aimed at increasing therapeutic efficacy
that will lead to more successful drug development. Chapters
logically build upon one another to show how to characterize the
pharmacology of any given molecule and allow for more informed
predictions of drug effects in all biological systems. New chapters
are dedicated to the interdisciplinary drug discovery environment
in both industry and academia, and special techniques involved in
new drug screening and lead optimization. This edition has been
fully revised to address the latest advances and research related
to real time kinetic assays, pluridimensional efficacy, signaling
bias, irreversible and chemical antagonism, allosterically-induced
bias, pharmacokinetics and safety, target and pathway validation,
and much more. With numerous valuable chapter summaries, detailed
references, practical examples and case studies throughout, Dr.
Kenakin successfully navigates a highly complex subject, making it
accessible for students, professors, and new researchers working in
pharmacology and drug discovery.
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