The importance of specific antibodies for the clearance of and
long-term resistance to many infectious pathogens has long been
appreciated.
In the last five years, data from of all of these areas of
research have coalesced, resulting in the emergence of a new and
more complete understanding of how antibody-mediated resistance to
pathogens is elaborated. The recent explosion of knowledge of
Toll-like receptor (TLR) specificity and function (Takeda et al.,
2003) has further embellished this understanding. It is now clear
that there is not only extensive overlap and cross-complementarity
in the action of innate and adaptive systems, but also
specialization of function of the various B cell subsets and the
types of antibodies they produce. This synergistic interaction of
multiple components of these systems is perhaps best exemplified in
antibody responses to bacteria. The contributors to this volume
will highlight this new perspective on antibody responses to
infection, as well as to convey its practical implications, such as
for contemporary vaccine design.
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