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Handbook of Cell-Penetrating Peptides (Hardcover, 2nd edition)
Loot Price: R7,940
Discovery Miles 79 400
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Handbook of Cell-Penetrating Peptides (Hardcover, 2nd edition)
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Donate to Against Period Poverty
Total price: R7,960
Discovery Miles: 79 600
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Since the first Handbook of Cell-Penetrating Peptides was prepared
in 2001, the wealth of new information on the use of these peptides
as transport systems has in fact served to confound the field. The
constant internal change in the field of cell-penetrating peptides
(CPPs) is due to recent research uncovering apparent ambiguities in
cellular uptake. There is still neither a common terminology nor a
uniform explanation for the penetrative mechanism of
cell-penetrating peptides. In this second edition of the Handbook
of Cell-Penetrating Peptides, the authors summarize the current
state of the field including recent reevaluations of earlier
studies of CPP mechanisms. Beginning with an overview of the
classes of peptides and their individual uptake mechanisms, from
the earlier lipid models to the more recent endocytotic pathways,
the book demonstrates the diversity and the opportunity for these
biologically active proteins to serve as future drug leads. The
text then covers the use of CPPs in gene modulation, addressing the
application of antisense and decoy oligonucleotides, as well as the
new avenue of research targeting specific tumors and other
tissues-questions that had barely been asked when the first edition
was published. By summarizing the diffuse information regarding
CPPs, including the ambiguities and variety of mechanisms, the
Handbook of Cell-Penetrating Peptides provides the most solid
foundation available from which to expand the potential of this
rapidly growing field of medicine.
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