A thorough understanding of cellular and molecular mechanisms
involved in the individual expression of toxic effects provides an
important tool for assessment of human health risk. New aspects,
major advances, and new areas in molecular and cellular biology and
toxicology demand updated sources of information to elucidate the
functional mechanics of human toxicology.
Mechanistic Toxicology: The Molecular Basis of How Chemicals
Disrupt Biological Targets, Second Edition retains the accessible
format of the original to present the general principles that link
xenobiotic-induced toxicity with the molecular pathways that
underlie these toxic effects. Extensively illustrated, this book
forms a conceptual bridge between multiple events at the molecular
level and the determinants of toxicity at the physiological and
cellular level. Specific examples of drugs, environmental
pollutants, and other chemicals are carefully chosen to illustrate
and highlight the fundamental mechanisms of toxicity at different
toxicokinetic and toxicodynamic levels. The book includes
references and review articles at the end of each chapter, as well
as boxed text for relevant review information on biological,
biochemical, molecular, and toxicological background. Linking
molecular pathways to more general biomedical contexts, the author
ensures that the reader is not lost in the details and instead
receives a broad understanding of the processes underlying
xenobiotic toxicity.
New in the Second Edition Updated chapters Types of toxic
responses Disruption of signal transduction by xenobiotics
Disruption of mitochondrial function Novel mechanisms derived from
systems toxicology
General
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