In all organs of the body, proteases have critical roles to play
both in normal development and functioning and in disease states.
The brain is no exception to this, with proteases having emerging
roles in synaptic plasticity, memory, neurodegenerative disorders
such as Alzheimera (TM)s, Parkinsona (TM)s and prion diseases,
ischemia and traumatic brain injury, inflammatory and infectious
diseases, and tumor progression. Proteases in the Brain brings
together a wide range of topics under this central theme and
highlights the large number of proteases involved in these normal
and disease processes.
Proteases in the Brain reviews the role and regulation of
proteases in, Alzheimera (TM)s disease, brain ischemia and
traumatic brain injury, human glioma, inflammatory and infectious
diseases of the central nervous system, metabolism of the prion
protein, modulating synaptic activity, multiple sclerosis, neuronal
plasticity and memory consolidation, Parkinsona (TM)s disease,
processing, conversion and inactivation of neuropeptides.
Proteases in the Brain is a timely and useful source of
information both for those well-versed in the role of proteases in
the brain, and for those who are beginning to realize the important
role of this family of enzymes in brain function and
dysfunction.
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