Synthesis of Bioactive Heterocycles using 3-Acetyl Quinolines (Paperback)

Quinoline heterocycles found to have diverse biological activities and 3-functionalised quinolines are important intermediates for the synthesis of various quinoline derivatives. 3-acetyl-4-hydroxy-quinolin-2(1H)-one and 6-chloro-3-acetyl-4-phenyl-2-methyl quinoline were chosen as intermediates for the synthesis of some novel quinoline derivatives. In particular, only a few methods are available for the synthesis of 3-acetyl-4-hydroxy-quinolin-2(1H)-one, which involve either two step or multistep reaction protocols. In the present work, a rapid, efficient and one pot procedure for the synthesis of 3-acetyl-4-hydroxy-quinolin-2(1H)-ones has been developed both by conventional and microwave assisted synthesis. The 3-acetyl quinolines were converted into chalcones which in turn converted to quinoline-3-yl pyrazolines and quinoline-3-yl isoxazolines and a few into 3-(2, 4-substitutedstyryl)isoxazolo 4,5-c]quinolin-4(5H)-ones. These compounds were explored for their anti-microbial and cyctotoxicity studies.

General

Imprint:	Lap Lambert Academic Publishing
Country of origin:	Germany
Release date:	August 2012
First published:	August 2012
Authors:	V. Vijayakumar • S. Sarveswari
Dimensions:	229 x 152 x 14mm (L x W x T)
Format:	Paperback - Trade
Pages:	248
ISBN-13:	978-3-659-20214-8
Categories:	Books > Science & Mathematics > Chemistry > Organic chemistry > General
LSN:	3-659-20214-2
Barcode:	9783659202148

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