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Evaluating Evidence of Mechanisms in Medicine - Principles and Procedures (Paperback, 1st ed. 2018)
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Evaluating Evidence of Mechanisms in Medicine - Principles and Procedures (Paperback, 1st ed. 2018)
Series: SpringerBriefs in Philosophy
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This book is open access under a CC BY license. This book is the
first to develop explicit methods for evaluating evidence of
mechanisms in the field of medicine. It explains why it can be
important to make this evidence explicit, and describes how to take
such evidence into account in the evidence appraisal process. In
addition, it develops procedures for seeking evidence of
mechanisms, for evaluating evidence of mechanisms, and for
combining this evaluation with evidence of association in order to
yield an overall assessment of effectiveness. Evidence-based
medicine seeks to achieve improved health outcomes by making
evidence explicit and by developing explicit methods for evaluating
it. To date, evidence-based medicine has largely focused on
evidence of association produced by clinical studies. As such, it
has tended to overlook evidence of pathophysiological mechanisms
and evidence of the mechanisms of action of interventions. The book
offers a useful guide for all those whose work involves evaluating
evidence in the health sciences, including those who need to
determine the effectiveness of health interventions and those who
need to ascertain the effects of environmental exposures.
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