Growth factors are a class of natural biologic mediators which
regulate key cellular events in tissue repair i.e. cell
proliferation, chemotaxis (directed migration), differentiation and
matrix synthesis via binding to specific cell surface receptors.
The expression of various growth and differentiation factors
following bone and soft tissue injury like what happens in a
periodontal disease may regulate the repair and regeneration
process. The capacity of these mitogenic growth factors to initiate
a programmed cellular cascade that results in the induction of bone
in a functionally conserved process utilized in embryonic
development recapitulated in post fetal osteogenesis and can be
re-exploited for the therapeutic initiation of periodontal tissue
regeneration.
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