The aim of the work is to evaluate the transdermal potential of
novel vesicular carrier, ethosomes, bearing aceclofenac,
Non-steroidal anti-inflammatory drugs having limited transdermal
permeation. Aceclofenac loaded ethosomal carriers were prepared,
optimized and characterized for vesicular shape and surface
morphology, scanning electronic microscopy, vesicular size,
entrapment efficiency, stability, in- vitro release study.The
formulation having 3% phospholipids content and 40% ethanol showing
the grater entrapment and optimal average vesicle size of
formulation was determine by Malvern Zetamaster & found 0.696 m
and zeta potential of formulation was -6.74 mV. The vesicular
suspension was kept in sealed vials (10ml) at 4 2 C and at room
temperature for 45 days no change is shown in the entrapment
efficiency. The optimized ethosomal formulation showed transdermal
flux (226.1 g/cm /hr) for ethanolic drug solution which is grater
then that of isopropyl alcohol solution (159.0 g/cm /hr). The
result advocates the potential of ethosome formulation to treat
rheumatic disease where facilitated penetration of the drug into
muscle and synovial fluid is desirable.
General
Is the information for this product incomplete, wrong or inappropriate?
Let us know about it.
Does this product have an incorrect or missing image?
Send us a new image.
Is this product missing categories?
Add more categories.
Review This Product
No reviews yet - be the first to create one!
Welcome to Loot.co.za!
Sign in / Register |Wishlists & Gift Vouchers |Help | Advanced search
