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Current Topics in Microbiology and Immunology (Paperback, Softcover reprint of the original 1st ed. 1982)
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Current Topics in Microbiology and Immunology (Paperback, Softcover reprint of the original 1st ed. 1982)
Series: Current Topics in Microbiology and Immunology, 97
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Many of the fundamental concepts of animal virology originated from
the study of the variola-cowpox-vaccinia virus system with vaccinia
virus serving as the type species (Fen- nerand Burnet 1957; Burnet
1959; Fenner 1976a, b). The importance of the Poxviridae(Fen- ner
1979) for the study of viruses as biologic entities and in defIning
the events which occur in virus-infected cells are exemplifIed by
investigations which: (a) described the epidemiology of a virus
disease in an animal population (Fenner1949, 1959b); (b) em- ployed
electron microscopy to study virion structure (Peters 1956,
Nagington and Home 1962, Dales and Siminovitch 1961) and to derme
the morphologic stages of virion develop- ment in infected cells
(Morgan et al. 1954, Dales 1963); (c) dermed and elaborated on the
mechanism of nongenetic reactivation for an animal virus (Joklik et
al. 1960a, Fenner and Woodroofe 1960, Hanafusa 1960); (d) described
the intracellular uncoating of a viral genome (Joklik 1964a, b);
(e) studied the antigenic structure and complexity of poxvirions
(Loh and Riggs 1961, Woodroofe and Fenner 1962, Appleyard et al.
1964, Appleyard and Westwood 1964); (1) described the use of
chemotherapy to treat viral infec- tions (Bauer et al. 1963); (g)
fIrst demonstrated the presence of virion-coded enzymes
encapsulated within virions (Kates and McAuslan 1967, Munyon et al.
1967); and (h) established the H -2 restriction of cytotoxic T-cell
killing of virus-infected cells in the murine system (Doherty et
al. 1976).
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