This is an "old-fashioned" book in the best sense of the term: It
is written by one man, and it is scholarly, complete, thorough, and
thoughtful. It is, in fact, a magnum opus wherein every aspect is
not only touched, but handled to perfec- tion. This is a treatise
that deserves careful reading by that increasing cadre of medical
specialists who understand the many ways in which mycoses threaten
human health and happiness, viz, the veterinarian, pharmaceutical
chemist, general practitioner, pharmacologist, and entire
consortium of researchers who study the biology, epidemiology,
pathogenesis, and treatment of fungus infec- tions. Mycoses
encompass a vast spectrum of diseases from trivial superficial skin
infections (tinea versicolor), troublesome ringworm infections (the
tineas of skin, hair, and nails), yeast infections (candidosis),
the systemic mycosis (cryptococcosis, histoplasmosis), and even the
deep-seated infections due to molds and saprophytic fungi
(aspergillosis). It is precisely because of the great variety of
causative organisms that the imidazoles deserve a special treatise.
They provide the first class of drugs with therapeutic activity
against all the important fungi which infect humans and animals.
Accordingly, their medical significance is great and the
possibilities endless. Morever, the imidazoles are the first
effective drugs whose antimicro- bial activities extend beyond the
usual designation of "broad-spectrum. " Broad-spectrum antibiotics,
for example, are either antifungal or antibacterial, not both as
the imidazoles are. To be sure, there have been other chemothera-
peutic compounds which inhibit bacteria and fungi.
General
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