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Cell Biological Aspects of Disease - The plasma membrane and lysosomes (Paperback, Softcover reprint of the original 1st ed. 1981)
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Cell Biological Aspects of Disease - The plasma membrane and lysosomes (Paperback, Softcover reprint of the original 1st ed. 1981)
Series: Boerhaave Series for Postgraduate Medical Education, 19
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W. TH. DAEMS This volume contains the papers presented at a
Boerhaave Course for Post graduate Education on The cell-biological
aspects of disease: the plasma membrane and lysosomes. One of the
purposes of this introduction is to explain the reasons for this
choice of subject. The first question which might be asked - why a
postgraduate course on the cell biological aspects of disease was
considered neccessary - is not difficult to answer: the impact of
the basic sciences on medicine is im measurably strong, and among
these sciences cell biology has contributed immensely to the
advances made in medicine during recent decades. It has provided
clues leading to general insights into etiology and pathogenesis as
well as to the development of diagnostic tools and a basis for
therapeutic methods. These insights derived mainly from the
still-increasing body of knowledge about the architecture of cells.
Initially, this knowledge arose from the notion that cells are
either simply bags full of enzymes or complex sponge like
structures in which all organelles are permanently interconnected
(Fig. 1). Later, this notion was replaced by a highly schematized
picture of the cell as an essentially two-compartment structure
(Fig. 2) in which cell organelles are discrete units separated from
each other by membranes, enabling each organelle to maintain an
internal microenvironment with optimal conditions for its specific
metabolic pro cesses."
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