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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Renin Angiotensin System and Cardiovascular Disease (Hardcover, 2010 ed.)
Loot Price: R4,471
Discovery Miles 44 710
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Renin Angiotensin System and Cardiovascular Disease (Hardcover, 2010 ed.)
Series: Contemporary Cardiology
Expected to ship within 10 - 15 working days
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Experimental and clinical evidence supports the view that the
activation of the renin angiotensin aldosterone system is involved
in cardiovascular pathology including hypertension, heart failure,
myocardial ischemia, and atherosclerosis. The present volume
describes the intricacies involved in these processes, including
the in?uence of prorenin/renin, angiotensin II, angiotensin (1-7),
and aldosterone on cardiac and vascular functions as well as their
involvement in the generation of cardiovascular diseases.
Fundamental aspects like intracellular signaling, regulation of
cell volume in the failing heart, and the presence of an intracrine
renin angiotensin system are discussed. Moreover, the role of the
mineralocorticoid receptor as an important c- ponent of the
intracrine renin angiotensin system and as a regulator of
extracellular action of angiotensin II is described, reinforcing
the view that aldosterone inhibitors are helpful in the treatment
of heart failure and hypertension. Let us hope the imp- tant topics
included here motivate basic and clinical investigators and
contribute to the development of new therapeutic approaches for
cardiovascular diseases. We want to thank the distinguished authors
and Humana Press for the opportunity to publish this important
book. Walmor C. DeMello Edward Frohlich v Contents 1 Systemic
Versus Local Renin Angiotensin Systems. An Overview ...1 Walmor C.
DeMello and Richard N. Re 2 Clinical Import of the Local Renin
Angiotensin Aldosterone Systems ...7 Edward D. Frohlich 3 Renin,
Prorenin, and the (Pro)Renin Receptor ...15 Genevieve Nguyen and
Aurelie Contrepas 4 Local Renin Angiotensin Systems in the
Cardiovascular System ...25 Richard N.
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