The use of antibiotics in the treatment of various infections of
humans caused by microbes has been a great success. Over the past
years there has been an increase in the resistance of
microorganisms against a large number of drugs. Keeping in view the
biological activity and medicinal importance of sulfonamides, new
sulfonamides are being synthesized. This book describes the
synthesis of N-benzyl-4-methylbenzenesulfonamide, its N-alkylated
derivatives and evaluation of their anti-microbial activity.
N-benzyl-4- methylbenzene sulfonamide was synthesized by the
condensation of benzyl amine with p-toluene
benzenesulfonylchloride. The solvent used for this reaction was
water.N-alkylated derivatives were prepared by reacting
N-benzyl-4-methylbenzenesulfonamide with different alkylating
agents and sodium hydride using DMF as solvent. The synthesized
compounds were characterized by different techniques like X-ray
crystallography, FT-IR, Elemental analyzer and melting point.
Evaluation of anti-microbial activity was carried out by employing
deep well method against different bacterial strains.The
synthesized compounds exhibited appreciable anti-microbial
activity.
General
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