Transcriptional Control of Lineage Differentiation in Immune Cells (Paperback, Softcover reprint of the original 1st ed. 2014)

Insights into the regulation of immune cell lineage differentiation and specification as well as into the control of lineage integrity, stability and plasticity are of fundamental importance to understanding innate and adaptive immune responses. In this volume, leading experts provide an up-to-date and comprehensive overview of recent advances in the transcriptional control mechanisms and transcription factor networks that regulate these processes in a variety of different immune cell lineages. The chapters cover the regulation of T versus B cell lineage choice, discuss early B cell development and pre-B cell leukemia prevention, address transcriptional control mechanisms during the differentiation, in regulatory T cells and iNKT cells, detail genomic switches in helper cell fate choice and plasticity and highlight the role of the BTB-zinc finger family of transcription factors in T cells. Moreover, the chapters discuss transcriptional networks in DCs, NK cells and in innate lymphoid cells. Together, the reviews illustrate key transcriptional control mechanisms that regulate the development and function of immune cells and demonstrate the impressive advances made over the last decade.

General

Imprint:	Springer International Publishing AG
Country of origin:	Switzerland
Series:	Current Topics in Microbiology and Immunology, 381
Release date:	August 2016
First published:	2014
Editors:	Wilfried Ellmeier • Ichiro Taniuchi
Dimensions:	235 x 155 x 18mm (L x W x T)
Format:	Paperback
Pages:	331
Edition:	Softcover reprint of the original 1st ed. 2014
ISBN-13:	978-3-319-37651-6
Categories:	Books > Science & Mathematics > Biology, life sciences > Cellular biology > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology > General
LSN:	3-319-37651-9
Barcode:	9783319376516

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