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Books > Medicine > Pre-clinical medicine: basic sciences > Physiology
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The Resistance Arteries - Integration of the Regulatory Pathways (Hardcover, 1995 ed.)
Loot Price: R2,854
Discovery Miles 28 540
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The Resistance Arteries - Integration of the Regulatory Pathways (Hardcover, 1995 ed.)
Series: Experimental Biology and Medicine, 26
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The Resistance Arteries is focused on the general issue of the
regulatory pathways in resistance arteries and comprises a
selection of timely overviews and up-to-date research studies
presented at the 4th International Symposium on Resistance
Arteries. These small vessels act as major controllers of blood
pressure, blood flow, and its distribution, and are involved in a
variety of pathological conditions. Vascular diameter is influenced
by a host of factors, some extrinsic to the smooth musc1e cells and
some intrinsic. One will find contributions in nearly all of the
five themes by which the book is organized; these address intra-and
extracellular interactions, and membrane receptor pathways using
vascular beds as diverse as the brain, he art, lung, kidney, and
skin. Basic physiological studies are inc1uded; these examine:
growth fac tors, vasoactive endothelium-derived nitric oxide, the
impacts of flow and stretch, myogenic mechanisms, calcium
regulation by protein kinase C, and signal transduction pathways of
the vascular smooth musc1e cell membrane receptors. Not only are
tissues from appropriate animal models exploited in most of these
reports, but many reflect the current increase in the use of human
tissue to elucidate vascular alterations of function and morphology
in hypertension, atherosclerosis, and ischemia. Noteworthy among
the many techniques used are: membrane permeabilization with
toxins, fura-2 for calcium determination, single cell
electrophysiology, and the application of confocal microscopy to
isolated, living vessels."
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