Untoward reactions to environmental chemicals, particularly when
a subject reports difficulties with exposures to chemicals of
diverse classes involving more than one organ system, have been
poorly understood and an area of great controversy. Studies of
airway inflammation induced by respiratory irritants have
established neurogenic inflammation as the mechanism for irritant
asthma and rhinitis. Remodeling of the airway after an acute
irritant exposure can lead to a heightened sensitivity to irritants
that persists. Recognition that rhinitis, while sometimes regarded
as a trivial disease, is associated with extra-airway
manifestations such as fatigue and disturbances of sleep, mood, and
cognition, further elucidates how chemical exposures can be serious
for susceptible individuals.
This book reviews current scientific understanding of irritant
airway inflammation and related conditions, including
cardiovascular effects of particulate exposures, airborne contact
dermatitis and irritant dermatitis, and the brain as a target organ
for both allergic and irritant reactions. It is essential reading
for physicians and other healthcare workers caring for patients
with environmental intolerances. Allergists, toxicologists,
occupational and environmental physicians, and pulmonologists will
find the materials particularly valuable. Patients and advocates
for those with chemical intolerances will also find the book of
interest.
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