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Ticlopidine, Platelets and Vascular Disease (Paperback, Softcover reprint of the original 1st ed. 1993)
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Ticlopidine, Platelets and Vascular Disease (Paperback, Softcover reprint of the original 1st ed. 1993)
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Blood platelets lack a nucleus. As a result their life span is
short and they cannot reproduce themselves. Platelets share these
qualities with the red blood cell. Plate lets and red blood cells,
nevertheless, serve vital roles in the body. One major function of
the platelet is its capacity to aggregate and thereby initiate
intravas cular coagulation which often underlies such major
diseases as myocardial infarc tion, cerebral infarction, and
pulmonary embolism. For this reason in recent years, medical
attention has been directed to drugs that inhibit platelet
aggregation. Aspirin was the first drug to be proven effective in
this area. Since then other drugs that share aspirin's fundamental
biochemical action, inhibition of platelet cyclooxygenase, have
also been studied. Very recently, ticlopidine, the first of what
promises to be a new class of drugs inhibiting platelet aggregation
and coagulation via an entirely different biochemical mechanism,
has been exten sively studied and clinically shown to be as
effective or more effective than aspirin in the prevention of
ischemic cardiovascular and cerebrovascular disease."
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