Cytokines and Joint Injury (Hardcover, 2004 ed.)

The purpose of this volume in the Progress in Inflammation Research series is to provide the biomedical and clinical researcher with a state-of-the-art insight in the role of cytokines in joint inflammation and joint destruction. This is of relevance for better understanding of key processes in diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Apart from the impact of old and novel cytokines on joint tissues, the various chapters address the issue of targeted therapy with biological response modifiers and future interventions with carefully designed inhibitors. Spe cial attention is given to elements of synovial cell activation, cell-cell interaction, cytokine interplay as well as mechanisms of cartilage destruction and bone erosion. In addition to an outline of the role of established cytokines, such as TNF, IL-l and IL-6, new information is given on the novel cytokines IL-15, IL-17 and IL-18 and their positioning in the complex cytokine interplay. Cytokine regulation of destructive enzymes, RANKL, the endogenous inhibitor OPG and their crucial roles as central players in joint erosion are highlighted. Together, the chapters provide a complete and balanced view on pivotal cytokines and joint pathology.

General

Imprint:	Birkhauser Verlag AG
Country of origin:	Switzerland
Series:	Progress in Inflammation Research
Release date:	May 2004
First published:	2004
Editors:	Wim B.Van Den Berg • Pierre Miossec
Dimensions:	235 x 155 x 19mm (L x W x T)
Format:	Hardcover
Pages:	296
Edition:	2004 ed.
ISBN-13:	978-3-7643-7001-5
Categories:	Books > Medicine > Surgery > Orthopaedics & fractures Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology > General Promotions
LSN:	3-7643-7001-7
Barcode:	9783764370015

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