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Second Generation of Calcium Antagonists (Paperback, 1991 ed.)
Loot Price: R1,541
Discovery Miles 15 410
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Second Generation of Calcium Antagonists (Paperback, 1991 ed.)
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"Another damned, thick, square book! Always scribble, scribble,
scribble! Eh! Mr. Gibbon?" From the Literary Memoirs of Willi am,
DUKE OF GLOUCESTER, 1743-1805 The foreword of any book is probably
the most difficult to write -not only because it stands at the
beginning of an exercise in writing and logic but because it is in
this chapter that areader can expect to find a clear and
unambiguous explanation of the author's reason for writing the book
and why some subject matter has been included and other subject
matter excluded. Potential readers ofthis book may not have an
inclination to question why some subject matter has been excluded
but instead may wonder why another book on calcium antagonists has
been published. However, it is arguable with some force that there
have been at least three recent developments in the field of
calcium antagonism which provide more than adequate support for the
view that another book on this topic is warranted. These
developments include: (i) an improved understanding of the chemical
structure, mode of action and architecture of the
voltage-activated, calcium antagonist-sensitive calcium channels
and their associated calcium-antagonist specific binding sites;
(ii) a more accurate appreciation ofhow and when the calcium
antagonists should be used in the management of a variety of
clinical dis orders including cerebral ischaemia atherosclerosis,
"mild" ischaemic heart disease, ventricular hyper trophy, impaired
ventricular relaxation and hypertension (to name but a few), and
(iii) the emergence of a second generation of calcium antagonists.
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