Learn why some drug discovery and development efforts succeed .
. . and others fail
Written by international experts in drug discovery and
development, this book sets forth carefully researched and analyzed
case studies of both successful and failed drug discovery and
development efforts, enabling medicinal chemists and pharmaceutical
scientists to learn from actual examples. Each case study focuses
on a particular drug and therapeutic target, guiding readers
through the drug discovery and development process, including drug
design rationale, structure-activity relationships, pharmacology,
drug metabolism, biology, and clinical studies.
"Case Studies in Modern Drug Discovery and Development" begins
with an introductory chapter that puts into perspective the
underlying issues facing the pharmaceutical industry and provides
insight into future research opportunities. Next, there are
fourteen detailed case studies, examining:
All phases of drug discovery and development from initial idea
to commercialization
Some of today's most important and life-saving medications
Drugs designed for different therapeutic areas such as
cardiovascular disease, infection, inflammation, cancer, metabolic
syndrome, and allergies
Examples of prodrugs and inhaled drugs
Reasons why certain drugs failed to advance to market despite
major research investments
Each chapter ends with a list of references leading to the
primary literature. There are also plenty of tables and
illustrations to help readers fully understand key concepts,
processes, and technologies.
Improving the success rate of the drug discovery and development
process is paramount to the pharmaceutical industry. With this book
as their guide, readers can learn from both successful and
unsuccessful efforts in order to apply tested and proven science
and technologies that increase the probability of success for new
drug discovery and development projects.
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