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Wnt/?-Catenin Signaling in Vertebrate Posterior Neural Development (Paperback, New)
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Wnt/?-Catenin Signaling in Vertebrate Posterior Neural Development (Paperback, New)
Series: Colloquium Series on Developmental Biology
Expected to ship within 10 - 15 working days
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The Wnt/ -catenin signaling pathway is a key regulator of cell fate
specification, differentiation, and growth in multiple systems
throughout the animal kingdom. In vertebrate posterior neural
development, Wnt/ -catenin signaling controls this complex
multistep process. It initially induces the posterior regions of
the nervous system, including the mid-hindbrain border, hindbrain,
spinal cord and neural crest, and then subsequently fine-tunes the
pattern of each region and determines the different cell fates
within them. In this review, we explore the function of the Wnt/
-catenin pathway during the formation of these specific posterior
neural regions. We have examined the important transcriptional
targets of the Wnt/ -catenin pathway acting downstream to mediate
its morphogenetic activity. Different regulatory networks are
activated in different posterior neural regions, and these networks
induce specific neural cell types in each region. Eludidating how
each of these networks specify different cell fates is crucial for
understanding the basic tenets of how Wnt morphogenetic activity
induces the posterior nervous system during the earliest stages of
vertebrate development. Table of Contents: Introduction / Making
the Neural Rear / Wnt Morphogenetic Activity in Neural Posterior
Induction / Induction of the Midbrain-Hindbrain Border / Induction
of the Hindbrain / Induction of the Spinal Cord / Downstream of
Wnt: Hindbrain or Spinal Cord? / Neural Crest Induction / Anti-Wnt
Anterior Determinants / The Role of Mesoderm and Specific Wnt
Ligands in Neural Patterning / Concluding Remarks / References
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