Integrating the clinical and engineering aspects of drug delivery,
this book offers a much needed comprehensive overview and
patient-oriented approach for enhanced drug delivery optimization
and advancement. Starting with an introduction to the subject and
pharmacokinetics, it explores advances for such topics as oral,
gastroretentive, intravitreal, and intrathecal drug delivery, as
well as insulin delivery, gene delivery, and biomaterials-based
delivery systems. It also describes drug delivery in cancer,
cardiac, infectious diseases, airway diseases, and obstetrics and
gynecology applications. Examining special clinical states
requiring innovative drug delivery modifications, such as
hypercoagulability often seen in pregnancy, cancer, and autoimmune
diseases, the book also discusses methods for improved drug
delivery in clinical settings using clinical end points, clinical
trials, simulations, and other venues. It also describes the latest
drug delivery advances involving nanomaterials, NEMS and MEMS
devices, hydrogels, microencapsulation, lipids, stem cells,
patches, and ultrasound. The book is rounded out by a chapter on
the FDA regulatory and bioethical challenges involved in advancing
drug delivery.
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