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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Lactoferrin and its Role in Wound Healing (Hardcover, 2012 ed.)
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Lactoferrin and its Role in Wound Healing (Hardcover, 2012 ed.)
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Lactoferrin is an iron-binding glycoprotein belonging to the
transferrin family. It acts as a defense in host animals against
microbes and viruses, since it has a broad spectrum of
antimicrobial and antiviral activities. Lactoferrin has been shown
to regulate the growth and differentiation of many types of cells.
The results of recent studies indicate that lactoferrin is a potent
regulator of dermal fibroblasts, and promotes cutaneous wound
healing. The collagen gel contraction, a model of wound contraction
during wound healing process, and migration of human fibroblasts
were enhanced by lactoferrin. LRP-1 (LDL Receptor related
Protein-1) acts as a signaling receptor for lactoferrin that
mediate fibroblast response to lactoferrin by activating ERK/MAPK
signaling pathway. In addition, lactoferrin promotes biosynthesis
of extracellular matrix (ECM) component such as type-I collagen and
hyaluronan. Hyaluronan is a major component of ECM in connective
tissue and promotes wound healing. The promoting effect of
lactoferrin on hyaluronan production was accompanied by promotion
of HAS2 (hyaluronan synthase 2) expression. These observations
suggest that lactoferrin promotes the wound healing by providing an
ECM that promotes fibroblast migration. Lactoferrin is also known
for its anti-inflammatory and immune modulating properties.
According to recent in vivo study, lactoferrin promotes wound
repair by promoting the early inflammatory phase of wound healing.
Based on this, recombinant human lactoferrin was subsequently
tested clinically in a Phase II trial in patients with diabetic
ulcers and was found to be effective. Lactoferrin should be further
evaluated in patients with diabetic and other types of ulcers.
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