Transporters in Drug Development - Discovery, Optimization, Clinical Study and Regulation (Paperback, Softcover reprint of the original 1st ed. 2013)

Transporters in Drug Development examines how membrane transporters can be dealt with in academic-industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters' impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process.

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Series:	AAPS Advances in the Pharmaceutical Sciences Series, 7
Release date:	August 2016
First published:	2013
Editors:	Yuichi Sugiyama • Bente Steffansen
Dimensions:	235 x 155 x 18mm (L x W x T)
Format:	Paperback
Pages:	317
Edition:	Softcover reprint of the original 1st ed. 2013
ISBN-13:	978-1-4939-5206-9
Categories:	Books > Medicine > General issues > Medical equipment & techniques > Medical research Books > Professional & Technical > Industrial chemistry & manufacturing technologies > Industrial chemistry > Pharmaceutical technology
LSN:	1-4939-5206-4
Barcode:	9781493952069

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