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Books > Professional & Technical > Industrial chemistry & manufacturing technologies > Industrial chemistry > Pharmaceutical technology
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Transporters in Drug Development - Discovery, Optimization, Clinical Study and Regulation (Paperback, Softcover reprint of the original 1st ed. 2013)
Loot Price: R5,377
Discovery Miles 53 770
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Transporters in Drug Development - Discovery, Optimization, Clinical Study and Regulation (Paperback, Softcover reprint of the original 1st ed. 2013)
Series: AAPS Advances in the Pharmaceutical Sciences Series, 7
Expected to ship within 10 - 15 working days
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Transporters in Drug Development examines how membrane transporters
can be dealt with in academic-industrial drug discovery and
pharmaceutical development as well as from a regulatory
perspective. The book describes methods and examples of in vitro
characterization of single transporters in the intestines, liver
and kidneys as well as characterization of substrate overlap
between various transporters. Furthermore, probes and biomarkers
are suggested for studies of the transporters' impact on the
pharmacokinetics of drug substrates/candidates interacting on
transporters. The challenges of translating in vitro observed
interaction of transporters into in vivo relevance are explored,
and the book highlights perspectives of applying targeted
proteomics and mechanistic modeling in this process.
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