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Ambiol as Base of New Effective Drugs (Hardcover)
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Ambiol as Base of New Effective Drugs (Hardcover)
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On example of the highly efficient plant growth regulator AMBIOL
(2-methyl-4-dimethylaminomethyl-5-hydroxybenzimidazol
dihydrochoride) - is as a complex antistress antioxidant,
possessing antimutagenical and radio protective properties. The
role of antioxidants in metabolism and the perspectives of
development and treatment.The peroxide concept theoretically
justifies application antioxidants as effective means of preventive
maintenance and treatment of atherosclerosis, ischemia illness of
heart, cerebral thrombosis. So, as a cardio protector in Russia was
for the first time used antioxidant Ionol (Dibunol) and rather
perspective use of Ambiol, which almost in 4 times active then
Ionol is represented. Synthetic inhibitors, substituting for action
natural antioxidants, destroyed during a irradiation, can brake the
free-radical oxidizing reactions in biomolecules, first of all in
lipids, and by that to block systems of strengthening of a
radiating affection. Anti-mutagenic activity of Ambiol (more, than
in 6 times to reduce frequency of scale - induced aberrations of
chromosomes) will give a basis to apply it in quality of a
anti-cancer preparation, as well as widely used in a oncology
practice the alkylating preparations - Myelosan, Sarcolisyn and
other. Besides Ambiol is possible to offer and for treatment of a
gastritis and of a pre-cancer disease of a stomach and a duodenum -
a ulcer, which successfully treat by the vitamin U, too, to the
point, donor of methyl groups and capable to block action of
certain cancer genes, causing cancer of breast. At pathogenesis of
broncholungic pathology are infringements of a structure and
function of membranes, activation of a free-radical oxidation and
syndrome of antioxidants-insufficiency. Potential danger of adverse
consequences of treatment by a oxygen is increased by
antioxidants-insufficiency. At toxic action on lung (nitro gases,
the ozone) first comes into effect as protection ascorbinic acid,
which is capable to break formation of super oxide radical and to
neutralize hydroxyl and peroxide radicals. Ambiol acts similarly. A
opportunity of restoration influence of Ambiol is not excluded on
the dehydrogenated form ascorbinic acid, with the subsequent its
activation and maintenance ascorbinic acid in the active form for
maintenance of a normal homeostasis free-radical oxidation. In view
of that the process of a aging of a cell is accompanied by
free-radical damages (first of all in a genetic apparatus and
biomembranes), by search the pharmacological means of extension of
life - gerontoprotectors - among antioxidants becomes justified.
The idea of medicinal correction of immunodeficiency is reduced to
selective effect on ill cells and its perverted functions. They
apply ascorbinic acid (will similarly act and Ambiol), lithium
salts, Levamysol, bacterial polysaccharides (will similarly act and
Ambiol). Ambiol promotes restoration of sexual cyclic recurrence
and of reproductive function, as well as sharply increases a
impregnation. The positive action of Ambiol is mainly explained by
that, having by antioxidant properties, it protects from
degradation the vitamins A, D, E, F, K; hormones -- estradiol,
testosterone, progesterone and enzymes (super oxide dismutase,
glutathione peroxidase, peroxidase, glutationreductase, katalase,
the cytochrome P450 ) and prevents accumulation in tissues of toxic
products of peroxide oxidation of lipids.
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