This book provides a unified framework for various currently available mathematical models that are used to analyze progression and regression in cancer development, and to predict its dynamics with respect to therapeutic interventions. Accurate and reliable model representations of cancer dynamics are milestones in the field of cancer research. Mathematical modeling approaches are becoming increasingly common in cancer research, as these quantitative approaches can help to validate hypotheses concerning cancer dynamics and thus elucidate the complexly interlaced mechanisms involved. Even though the related conceptual and technical information is growing at an exponential rate, the application of said information and realization of useful healthcare devices are lagging behind. In order to remedy this discrepancy, more interdisciplinary research works and course curricula need to be introduced in academic, industrial, and clinical organizations alike. To that end, this book reformulates most of the existing mathematical models as special cases of a general model, allowing readers to easily get an overall idea of cancer dynamics and its modeling. Moreover, the book will help bridge the gap between biologists and engineers, as it brings together cancer dynamics, the main steps involved in mathematical modeling, and control strategies developed for cancer management. This also allows readers in both medical and engineering fields to compare and contrast all the therapy-based models developed to date using a single source, and to identify unexplored research directions.

"Fault Detection and Isolation: Multi-Vehicle Unmanned System" deals with the design and development of fault detection and isolation algorithms for unmanned vehicles such as spacecraft, aerial drones and other related vehicles. Addressing fault detection and isolation is a key step towards designing autonomous, fault-tolerant cooperative control of networks of unmanned systems. This book proposes a solution based on a geometric approach, and presents new theoretical findings for fault detection and isolation in Markovian jump systems. Also discussed are the effects of large environmental disturbances, as well as communication channels, on unmanned systems. The book proposes novel solutions to difficulties like robustness issues, as well as communication channel anomalies. "Fault Detection and Isolation: Multi-Vehicle Unmanned System" is an ideal book for researchers and engineers working in the fields of fault detection, as well as networks of unmanned vehicles.

Understanding phytochemical-gene interactions provides the basis for individualized therapies to promote health as well as prevent and treat disease. The authors of Phytochemicals: Nutrient-Gene Interactions examine the interactions between phytochemicals and the human genome and discuss the impact these interactions have on health, aging, and chronic conditions such as inflammation, heart disease, obesity, type II diabetes mellitus, and cancer.

Keeping pace with the most important trends in phytochemical research, the authors accentuate the latest understanding on the use of controlled clinical trials, new screening technologies, and the completed human genome project for researching the pharmacokinetics, safety, and efficacy of phytochemicals. The book covers a balanced range of topics beginning with experimental strategies and methodologies for identifying significant interactions between diet, genetic variants, and different markers of cardiovascular disease, inflammation, and obesity. Different authors explain the mechanisms of protective action that link diets rich in omega-3 fatty acids, unsaturated fats, fruits, vegetables, and whole grains with a decreased risk of chronic and degenerative diseases. They also review and summarize epidemiological research on plant-based foods and dietary patterns supporting the beneficial role of phytochemicals in health promotion and disease prevention.

Phytochemicals: Nutrient-Gene Interactions illustrates the growing role of nutrigenomics and nutrigenetics in disease prevention and in the responsible development of safe and effective phytochemical products within the food, pharmaceutical, and supplement industries.

This cutting-edge handbook brings together an international roster of scholars to examine many facets of comics and graphic novels. Contributor essays provide authoritative, up-to-date overviewsof the major topics and questions within comic studies, offering readers a truly global approach to understanding the field. Essays examine: the history of the temporal, geographical, and formal development of comics, including topics like art comics, manga, comix, and the comics code; issues such as authorship, ethics, adaptation, and translating comics; connections between comics and other artistic media (drawing, caricature, film) as well as the linkages between comics and other academic fields like linguistics and philosophy; new perspectives on comics genres, from funny animal comics to war comics to romance comics and beyond. The Routledge Companion to Comics expertly organizes representative work from a range of disciplines, including media and cultural studies, literature, philosophy, and linguistics. More than an introduction to the study of comics, this book will serve as a crucial reference for anyone interested in pursuing research in the area, guiding students, scholars, and comics fans alike.

Phytochemicals as Bioactive Agents focuses on the mechanisms of action of phytochemicals identified as displaying bioactivity in the prevention of cancer, heart disease and other diseases, and the prospects for developing functional foods containing these bioactive compounds. An internationally recognized group of experts presents the latest research findings on the antimutagenic and anticarcinogenic effects of tea and tea constituents; chemoprevention provided by plants in the family Cruciferae and genus Allium by altering carcinogen metabolism; anticarcinogenic effects of carotenoids and curcumins; the chemistry and application of alfalfa saponins; the bioactive components of rice bran and rice oil; the effects of garlic on lowering serum cholesterol; and using phytochemicals to optimize gastrointestinal tract health and function. Also included are chapters on: strategies to identify bioactive phytochemicals in foods; the design, conduct and interpretation of clinical trials to test phytochemicals for expected bioactivity; compounds that have potential use as phytochemical antimicrobial agents (PAM) in food processing; and designing bioactive functional foods.
This book will be of interest to food scientists and technologists, food process engineers, biochemists, nutritionists, public health professionals, and entrepreneurs involved in the design, processing, and marketing of new functional food products.

Are soy isoflavones neuroprotective? Just how different is one species of Echinacea from another? Which phytochemicals will be effective as therapeutic agents in vivo? Supported by solid scientific research, Phytochemicals in Nutrition and Health helps provide answers to these and other probing questions concerning the mechanisms of action associated with beneficial phytochemical groups. It examines new areas such as the efficacy and safety of medicinal herbs, the use of biotechnology to manipulate and enhance the phytochemical profiles of various plants, and the pharmacokinetics of phytochemicals in humans. The editors also expand discussion presented in their previous books on phytochemicals. They explore new research on phytochemicals in the Vaccinium family (cranberries, blueberries and bilberries), wine, and oilseeds, and the biological activity of Echinacea in humans. Additional chapters present new information about isothiocyanates, lycopene, carotenoids other than beta-carotene, tocotrienols, and phytoestrogens. Highlighting phytochemicals that have significant potential for promoting health or preventing disease, Phytochemicals in Nutrition and Health expands discussions of appropriate research methodologies and new technologies in this exciting field.

The fastest growing demographic in both developed and developing societies around the world, the elderly bring unique medical and financial health-care burdens. In response to this phenomenon, a large and growing body of research is directed toward the science of healthy aging. A substantial amount of observational data points to the consumption of a plant-based diet as a factor in lowering the risk of multiple chronic degenerative age-related diseases. The 6th International Phytochemical Conference, Phytochemicals: Aging and Health, focused on the particular concerns of nutrition in the aging population, as well as new aspects of research methodology, real-world applications, and updates or expansions of previously introduced topics. Drawn from the illustrious panel of scientists and researchers who spoke at the conference, Phytochemicals: Aging and Health begins by highlighting the prevailing theories on aging, including dietary manipulation and the role of phytochemical medicinals or supplements in health. Contributions present state-of-the-art methodologies for polyphenolic analysis, bioavailability, and metabolism-crucial tools that answer pressing questions such as "are there age related changes in flavonoid bioavailability?" The following chapters provide research results on botanicals and inflammation, green tea formulations and skin health, and the effects of phytochemicals on vision, brain function, and cardiovascular disease. The book concludes with forward-looking discussions on applying nutrient-gene interaction research findings to individual dietary recommendations, along with the step-by-step process to commercialize botanical products for allergy relief. Continuing to introduce the highest-quality, groundbreaking research, Phytochemicals: Aging and Health provides pragmatic information for food companies, supplement manufacturers, and researchers interested in developing functional foods and nutraceuticals for the aging population.

This cutting-edge handbook brings together an international roster of scholars to examine many facets of comics and graphic novels. Contributor essays provide authoritative, up-to-date overviewsof the major topics and questions within comic studies, offering readers a truly global approach to understanding the field. Essays examine: the history of the temporal, geographical, and formal development of comics, including topics like art comics, manga, comix, and the comics code; issues such as authorship, ethics, adaptation, and translating comics; connections between comics and other artistic media (drawing, caricature, film) as well as the linkages between comics and other academic fields like linguistics and philosophy; new perspectives on comics genres, from funny animal comics to war comics to romance comics and beyond. The Routledge Companion to Comics expertly organizes representative work from a range of disciplines, including media and cultural studies, literature, philosophy, and linguistics. More than an introduction to the study of comics, this book will serve as a crucial reference for anyone interested in pursuing research in the area, guiding students, scholars, and comics fans alike.

This book provides a unified framework for various currently available mathematical models that are used to analyze progression and regression in cancer development, and to predict its dynamics with respect to therapeutic interventions. Accurate and reliable model representations of cancer dynamics are milestones in the field of cancer research. Mathematical modeling approaches are becoming increasingly common in cancer research, as these quantitative approaches can help to validate hypotheses concerning cancer dynamics and thus elucidate the complexly interlaced mechanisms involved. Even though the related conceptual and technical information is growing at an exponential rate, the application of said information and realization of useful healthcare devices are lagging behind. In order to remedy this discrepancy, more interdisciplinary research works and course curricula need to be introduced in academic, industrial, and clinical organizations alike. To that end, this book reformulates most of the existing mathematical models as special cases of a general model, allowing readers to easily get an overall idea of cancer dynamics and its modeling. Moreover, the book will help bridge the gap between biologists and engineers, as it brings together cancer dynamics, the main steps involved in mathematical modeling, and control strategies developed for cancer management. This also allows readers in both medical and engineering fields to compare and contrast all the therapy-based models developed to date using a single source, and to identify unexplored research directions.

As control systems become more complex and are expected to perform tasks in unknown and extreme environments, they may be subject to various types of faults in their sensors, actuators or other components. It is crucial to be able to diagnose the occurrence of faults and to repair them in order to maintain, guarantee, and improve the overall safety, reliability, and performance of the systems. This book addresses the design challenges of developing and implementing novel integrated fault diagnosis and control technologies for complex linear systems. Integrated Fault Diagnosis and Control Design of Linear Complex Systems considers linear time-invariant (LTI) systems under both time- and event-triggered frameworks. The book initially develops novel methodologies for the problem of integrated fault diagnosis and control of LTI systems to address current design challenges. The results obtained are then extended to a number of complex linear systems, specifically to Markovian jump systems as well as to cooperative multi-agent systems.

Once Upon a Time is a collection of essays in the philosophy of literature with two central themes: the significance of story –telling for us and the question of whether the novel, perhaps the art form most closely associated with story-telling, is a legitimate source of human knowledge. Leading philosopher of art Peter Kivy explores why human beings are so enthralled by being told stories and whether story-telling is a significant source of knowledge. Starting with a study of Aristotle's Poetics, Kivy then undertakes a critical discussion of Noel Carroll's suggestion that our interaction with the artists of the past is a kind of "conversation." He goes on to defend the thesis that one of the legitimate artistic pleasures we take in novel-reading is the acquiring of knowledge and, furthermore, that the silent reading of a novel is a kind of performance, making the novel one of the performing arts. The volume concludes with a chapter about jokes, and, in particular, whether it is immoral to tell or be amused by an "immoral" joke. This volume of essays is a must-read for anyone seriously interested in literature and the conceptual problems it may raise for philosophers.

"Fault Detection and Isolation: Multi-Vehicle Unmanned System" deals with the design and development of fault detection and isolation algorithms for unmanned vehicles such as spacecraft, aerial drones and other related vehicles. Addressing fault detection and isolation is a key step towards designing autonomous, fault-tolerant cooperative control of networks of unmanned systems. This book proposes a solution based on a geometric approach, and presents new theoretical findings for fault detection and isolation in Markovian jump systems. Also discussed are the effects of large environmental disturbances, as well as communication channels, on unmanned systems. The book proposes novel solutions to difficulties like robustness issues, as well as communication channel anomalies. "Fault Detection and Isolation: Multi-Vehicle Unmanned System" is an ideal book for researchers and engineers working in the fields of fault detection, as well as networks of unmanned vehicles.

The fastest growing demographic in both developed and developing societies around the world, the elderly bring unique medical and financial health-care burdens. In response to this phenomenon, a large and growing body of research is directed toward the science of healthy aging. A substantial amount of observational data points to the consumption of a plant-based diet as a factor in lowering the risk of multiple chronic degenerative age-related diseases. The 6th International Phytochemical Conference, Phytochemicals: Aging and Health, focused on the particular concerns of nutrition in the aging population, as well as new aspects of research methodology, real-world applications, and updates or expansions of previously introduced topics. Drawn from the illustrious panel of scientists and researchers who spoke at the conference, Phytochemicals: Aging and Health begins by highlighting the prevailing theories on aging, including dietary manipulation and the role of phytochemical medicinals or supplements in health. Contributions present state-of-the-art methodologies for polyphenolic analysis, bioavailability, and metabolism-crucial tools that answer pressing questions such as "are there age related changes in flavonoid bioavailability?" The following chapters provide research results on botanicals and inflammation, green tea formulations and skin health, and the effects of phytochemicals on vision, brain function, and cardiovascular disease. The book concludes with forward-looking discussions on applying nutrient-gene interaction research findings to individual dietary recommendations, along with the step-by-step process to commercialize botanical products for allergy relief. Continuing to introduce the highest-quality, groundbreaking research, Phytochemicals: Aging and Health provides pragmatic information for food companies, supplement manufacturers, and researchers interested in developing functional foods and nutraceuticals for the aging population.

Once Upon a Time is a collection of essays in the philosophy of literature with two central themes: the significance of story –telling for us and the question of whether the novel, perhaps the art form most closely associated with story-telling, is a legitimate source of human knowledge. Leading philosopher of art Peter Kivy explores why human beings are so enthralled by being told stories and whether story-telling is a significant source of knowledge. Starting with a study of Aristotle's Poetics, Kivy then undertakes a critical discussion of Noel Carroll's suggestion that our interaction with the artists of the past is a kind of "conversation." He goes on to defend the thesis that one of the legitimate artistic pleasures we take in novel-reading is the acquiring of knowledge and, furthermore, that the silent reading of a novel is a kind of performance, making the novel one of the performing arts. The volume concludes with a chapter about jokes, and, in particular, whether it is immoral to tell or be amused by an "immoral" joke. This volume of essays is a must-read for anyone seriously interested in literature and the conceptual problems it may raise for philosophers.

In 1954, industry legends Joe Simon and Jack Kirby founded Mainline Publications to publish their own comics during that turbulent era in comics history. The four titles—Bullseye, Foxhole, Police Trap, and In Love—looked to build off their reputation as hit makers in the Western, War, Crime, and Romance genres, but the 1950s backlash against comics killed any chance at success, and Mainline closed its doors just two years later. For the first time, TwoMorrows Publishing is compiling the best of Simon & Kirby’s Mainline comics work, including all of the stories with S&K art, as well as key tales with contributions by Mort Meskin and others. After the company’s dissolution, their partnership ended with Simon leaving comics for advertising, and Kirby taking unused Mainline concepts to both DC and Marvel. This collection bridges the gap between Simon & Kirby’s peak with their 1950s romance comics, and the lows that led to Kirby’s resurgence with Challengers of the Unknown and the early Marvel Universe. With loving art restoration by Chris Fama, and an historical overview by John Morrow to put it all into perspective, the Best of Simon & Kirby’s Mainline Comics presents some of the final, and finest, work Joe and Jack ever produced!

Understanding phytochemical-gene interactions provides the basis for individualized therapies to promote health as well as prevent and treat disease. The authors of Phytochemicals: Nutrient-Gene Interactions examine the interactions between phytochemicals and the human genome and discuss the impact these interactions have on health, aging, and chronic conditions such as inflammation, heart disease, obesity, type II diabetes mellitus, and cancer. Keeping pace with the most important trends in phytochemical research, the authors accentuate the latest understanding on the use of controlled clinical trials, new screening technologies, and the completed human genome project for researching the pharmacokinetics, safety, and efficacy of phytochemicals. The book covers a balanced range of topics beginning with experimental strategies and methodologies for identifying significant interactions between diet, genetic variants, and different markers of cardiovascular disease, inflammation, and obesity. Different authors explain the mechanisms of protective action that link diets rich in omega-3 fatty acids, unsaturated fats, fruits, vegetables, and whole grains with a decreased risk of chronic and degenerative diseases. They also review and summarize epidemiological research on plant-based foods and dietary patterns supporting the beneficial role of phytochemicals in health promotion and disease prevention. Phytochemicals: Nutrient-Gene Interactions illustrates the growing role of nutrigenomics and nutrigenetics in disease prevention and in the responsible development of safe and effective phytochemical products within the food, pharmaceutical, and supplement industries.

Through much of the twentieth century, philosophical thinking about works of art, design, and other aesthetic products has emphasized intuitive and reflective methods, often tied to the idea that philosophy's business is primarily to analyze concepts. This 'philosophy from the armchair' approach contrasts with methods used by psychologists, sociologists, evolutionary thinkers, and others who study the making and reception of the arts empirically. How far should philosophers be sensitive to the results of these studies? Is their own largely a priori method basically flawed? Are their views on aesthetic value, interpretation, imagination, and the emotions of art to be rethought in the light of best science? The essays in this volume seek answers to these questions, many through detailed studies of problems traditionally regarded as philosophical but where empirical inquiry seems to be shedding interesting light. No common view is looked for or found in this volume: a number of authors argue that the current enthusiasm for scientific approaches to aesthetics is based on a misunderstanding of the philosophical enterprise and sometimes on misinterpretation of the science; others suggest various ways that philosophy can and should accommodate and sometimes yield to the empirical approach. The editors provide a substantial introduction which sets the scene historically and conceptually before summarizing the claims and arguments of the essays.

Musical listening, looking at paintings and literary creation are activities that involve perceptual and cognitive activity and so are of interest to psychologists and other scientists of the mind. What sorts of interest should philosophers of the arts take in scientific approaches to such issues? Opinion currently ranges across a spectrum, with 'take no notice' at one end and 'abandon traditional philosophical methods' at the other. This collection of essays, originating in a Royal Institute of Philosophy conference at the Leeds Art Gallery in 2012, represents many of the most interesting positions along that spectrum. Contributions address issues concerning aesthetic testimony, the processing and appreciation of poetry, the aesthetics of disgust, imagination, genre, evolutionary constraints on art appreciation, creativity, musical cognition and the limitations or productiveness of empirical enquiry for philosophical aesthetics.

Through much of the twentieth century, philosophical thinking about works of art, design, and other aesthetic products has emphasized intuitive and reflective methods, often tied to the idea that philosophy's business is primarily to analyze concepts. This 'philosophy from the armchair' approach contrasts with methods used by psychologists, sociologists, evolutionary thinkers, and others who study the making and reception of the arts empirically. How far should philosophers be sensitive to the results of these studies? Is their own largely a priori method basically flawed? Are their views on aesthetic value, interpretation, imagination, and the emotions of art to be rethought in the light of best science? The essays in this volume seek answers to these questions, many through detailed studies of problems traditionally regarded as philosophical but where empirical inquiry seems to be shedding interesting light. No common view is looked for or found in this volume: a number of authors argue that the current enthusiasm for scientific approaches to aesthetics is based on a misunderstanding of the philosophical enterprise and sometimes on misinterpretation of the science; others suggest various ways that philosophy can and should accommodate and sometimes yield to the empirical approach. The editors provide a substantial introduction which sets the scene historically and conceptually before summarizing the claims and arguments of the essays.

The Art of Comics is the first-ever collection of essays published in English devoted to the philosophical topics raised by comics and graphic novels. In an area of growing philosophical interest, this volume constitutes a great leap forward in the development of this fast expanding field, and makes a powerful contribution to the philosophy of art. * The first-ever anthology to address the philosophical issues raised by the art of comics * Provides an extensive and thorough introduction to the field, and to comics more generally * Responds to the increasing philosophical interest in comic art * Includes a preface by the renowned comics author Warren Ellis * Many of the chapters are illustrated, and the book carries a stunning cover by the rising young comics star David Heatley

The Art of Comics is the first-ever collection of essays published in English devoted to the philosophical topics raised by comics and graphic novels. In an area of growing philosophical interest, this volume constitutes a great leap forward in the development of this fast expanding field, and makes a powerful contribution to the philosophy of art. The first-ever anthology to address the philosophical issues raised by the art of comics Provides an extensive and thorough introduction to the field, and to comics more generally Responds to the increasing philosophical interest in comic art Includes a preface by the renowned comics author Warren Ellis Many of the chapters are illustrated, and the book carries a stunning cover by the rising young comics star David Heatley

Are soy isoflavones neuroprotective? Just how different is one species of Echinacea from another? Which phytochemicals will be effective as therapeutic agents in vivo? Supported by solid scientific research, Phytochemicals in Nutrition and Health helps provide answers to these and other probing questions concerning the mechanisms of action associated with beneficial phytochemical groups. It examines new areas such as the efficacy and safety of medicinal herbs, the use of biotechnology to manipulate and enhance the phytochemical profiles of various plants, and the pharmacokinetics of phytochemicals in humans.

The editors also expand discussion presented in their previous books on phytochemicals. They explore new research on phytochemicals in the Vaccinium family (cranberries, blueberries and bilberries), wine, and oilseeds, and the biological activity of Echinacea in humans. Additional chapters present new information about isothiocyanates, lycopene, carotenoids other than beta-carotene, tocotrienols, and phytoestrogens. Highlighting phytochemicals that have significant potential for promoting health or preventing disease, Phytochemicals in Nutrition and Health expands discussions of appropriate research methodologies and new technologies in this exciting field.