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Unlike some other reproductions of classic texts (1) We have not
used OCR(Optical Character Recognition), as this leads to bad
quality books with introduced typos. (2) In books where there are
images such as portraits, maps, sketches etc We have endeavoured to
keep the quality of these images, so they represent accurately the
original artefact. Although occasionally there may be certain
imperfections with these old texts, we feel they deserve to be made
available for future generations to enjoy.
Finally a book that teaches both the philosophy and step-by-step
instructions for building wealth through the financial planning
process.
An easy to read and understanding guide to the steps of
constructing a financial plan. The author does a masterful job of
explaining a complex topic in a way that makes it easy to
understand and implement.
By comparing a financial plan to a sailboat, readers are able to
vision a financial plan that has both defensive and offensive
elements.
The financial plan is tailored to the objectives, timeframe and
risk tolerance of the reader. At the center of the plan are the
financial goals that the reader chooses. This makes the book
indispensable in creating a very personal and useful tool for
realizing life-time goals.
Epstein-Barr virus (EBV) is a human gamma herpes virus that is best
known for being the causative agent of infectious mononucleosis in
man. A fascinating feature of this virus is its ability to persist
in the host, and it is estimated that more than 95% of adults are
carriers of the virus. Importantly, EBV can transform latently
infected primary cells from healthy individuals into cancerous
ones, thereby causing important human cancers such as B-cell
neoplasms (e.g. Burkitt's lymphoma and Post-transplant lymphomas),
certain forms of T-cell lymphoma, and some epithelial tumors (e.g.
gastric carcinomas). Understanding viral latency, what triggers
viral reactivation and the mechanism of transformation of normal
host cells into malignant cells are critical for the development of
strategies for the prevention and control of this intriguing virus
and related cancers. In this book, expert EBV virologists
comprehensively review this important subject from a genetic,
biochemical, immunological, and cell biological perspective. Topics
include: latent infections, EBV leader protein, EBNA-1 in viral DNA
replication and persistence, EBNA-2 in transcription activation of
viral and cellular genes, the nuclear antigen family 3 in
regulation of cellular processes, molecular profiles of EBV
latently infected cells, latent membrane protein 1 oncoprotein,
regulation of latency by LMP2A, role of noncoding RNAs in
EBV-induced cell growth and transformation, and the regulation of
EBV latency by viral lytic proteins. This book is essential reading
for all EBV virologists, as well as clinical and basic scientists
working on oncogenic viruses.
Details improved approaches to the design of power oscillators that
employ more analysis and theory and less empirical work than
conventional design procedures. It bridges fundamental device
physics and the development and implementation of practical
microwave and millimeterwave power oscillators.
The acknowledgment that viruses are potent biological factors in
driving many cancers have seen a dramatic upsurge in recent years
in large part to the success of the human papilloma virus vaccine
against invasive cervical carcinomas and followed by the awarding
of the noble prize in medicine in 2008 to Dr. Harald zurHausen who
identified the link between papilloma virus and cervical cancers.
Over the last few years there have been some volumes addressing
different aspects of viruses and cancers and to some extent
focusing on the DNA viruses, more specifically the human DNA
viruses. This proposed volume will attempt to review and address
the major gaps in current knowledge in DNA viruses as well as RNA
viruses bringing a historical perspective of where studies began to
a more recent molecular approach and vaccine successes in tumor
viruses. We will also cover other known oncogenic viruses
associated cancers in other mammals in addition to humans.
Epstein-Barr virus (EBV) is a human gamma herpes virus that remains
one of the most successful viral parasites known to man. It is the
etiological agent of infectious mononucleosis and is the major
biological cofactor contributing to a number of human cancers
including B-cell neoplasms (e.g. Burkitt's lymphoma, Hodgkin's
disease and immunoblastic lymphomas), certain forms of T-cell
lymphoma, and some epithelial tumors (e.g. nasopharyngeal
carcinomas and gastric carcinomas). The virus has the unique
ability to persist in the infected, apparently healthy host for
life. Understanding the molecular interaction between EBV and its
human host, the ability of the virus to modulate the host immune
system, its ability to hide in B-memory cells and factors that
trigger viral reactivation are fundamental to understanding the
cellular and molecular pathogenesis of the virus. This is critical
for the development of strategies for the prevention and control of
infection and disease. In this book, world renowned EBV experts
provide a critical and comprehensive review of every aspect of this
important virus. By integrating genetic, immunologic, and cell
biologic approaches to elucidate pathogenesis, penetrating new
insights into the molecular and cellular interaction between EBV
and its human host have emerged. Topics covered include: discovery,
history and seroepidemiology, EBV and the immune response, EBV
genetics, EBV infection and persistence, latency, lytic proteins
and reactivation control, vaccine approaches, animal models, and
the future of EBV studies. This is essential reading for all EBV
virologists as well as clinical and research scientists working on
oncogenic viruses.
Debates on reparations for slavery have emerged on national and
international levels. However, much of the discourse centers on the
"legitimate" slave trade. Few people are cognizant of the fact that
the transatlantic slave trade consisted of both a "legal" trade and
an illegal trade that began after January 1, 1808. Despite
statutory prohibitions against slave smuggling, American citizens
continued to smuggle African captives into the United States up and
beyond the threshold of the Civil War. The Slave Ship Clotilda and
the Making of AfricaTown, USA is the only well-documented work of
serious nonfiction that chronicles the transatlantic smuggling
expedition of the slaver Clotilda during the slave trade's illegal
period, dramatizing the plight of her captives from the point of
capture in the West African interior to the point of disembarkation
in Mobile, Alabama in 1860, and tracing the specific means by which
the captives triumphed over their tragedy. Thirty members of that
fateful cargo established AfricaTown in Alabama, where many of
their descendants still live. In 1927, Zora Neale Hurston
interviewed Cudjo Kazoola, the last survivor of the Clotilda. In
The Slave Ship Clotilda and the Making of AfricaTown, USA Natalie
S. Robertson uses ethnography, cartography, linguistics, and oral
history to connect the story of the Clotilda captives to their
origins in Africa, through their ordeals on the middle passage, all
the way to the issue of reparations in the present day. She
incorporates indigenous African perspectives, Hurston's interviews,
and sources such as the Clotilda's log, meshing diverse voices into
a narrative that reveals the centrality of slavery, Africanisms,
and resistancein American culture even today.
The 2000 edition of this long running and highly respected series,
contains the best papers from the Ergonomics Society Annual
Conference in 2000. The individual papers provide insight into
current practice, presents new research findings, and forms an
invaluable reference source.
In addition to mainstream ergonomists and human factors
specialists, Contemporary Ergonomics 2000 will appeal to all those
who have an interest in peoples' interaction with their working and
leisure environment - including designers, manufacturing and
production engineers, health and safety specialists, occupational,
applied and industrial psychologists and applied physiologists.
What is this called 'ergonomics'? For over ten years this question
has been answered by the books which comprise our series
Contemporary Ergonomics. Contemporary Ergonomics are the
proceedings of the Annual Conferences of the Ergonomics Society.
Comprehensively covering the wide range of topics that ergonomics
embraces, the papers provide insights into current practice as well
as presenting new research findings and are a valuable source of
references. This volume of Contemporary Ergonomics contains a short
summary of the Donald Broadbent Memorial Address, a Keynote Address
and over 90 papers given at the 1996 Annual Conference of the
Ergonomics Society held at the University of Leicester in April
1996.
The study of Burkitt's lymphoma is now in its 6 decade beginning
with its discovery by Dr. Dennis Burkitt in equatorial Africa in
the mid to late 1950's. A large body of information is available
which provides a current understanding of the underlying molecular
changes that are linked to the initiation and development of
Burkitt's lymphoma. This proposed volume will provide a
comprehensive view of Burkitt's Lymphoma from the diagnosis to
potential animal models for this disease and include a view from
physicians who have a up close view of the patients in populations
where the disease is rampant. We expect that this will be an
excellent resource for Medical students and faculty as well as
educated laypersons who have a person interest in the disease.
This is a composition of papers presented at the Annual Conference
of the Ergonomics Society. Featured is a broad spectrum of research
from many of the leading specialists in fields including consumer
ergonomics and organization ergonomics.
This book ventures into a new and exciting area of discovery that
directly ties our current knowledge of cancer to the discovery of
microorganisms associated with different types of cancers. Recent
studies demonstrate that microorganisms are directly linked to the
establishment of cancers and that they can also contribute to the
initiation, as well as persistence of, the cancers. Microbiome and
Cancer covers the current knowledge of microbiome and its
association with human cancers. It provides important reading for
novices, senior undergraduates in cancer and microbiology, graduate
students, junior investigators, residents, fellows and established
investigators in the fields of cancer and microbiology. We cover
areas related to known, broad concepts in microbiology and how they
can relate to the ongoing discoveries of the micro-environment and
the changes in the metabolic and physiologic states in that
micro-environment, which are important for the ongoing nurturing
and survival of the poly-microbial content that dictates activities
in that micro-environment. We cover the interactions of
microorganisms associated with gastric carcinomas, which are
important for driving this particular cancer. Additional areas
include oral cancers, skin cancers, ovarian cancers, breast
cancers, nasopharyngeal cancers, lung cancers, mesotheliomas,
Hodgkin's and non-Hodgkin's lymphomas, glioblastoma multiforme,
hepatocellular carcinomas, as well as the inflammatory response
related to the infectious agents in cancers. This book covers the
metabolic changes that occur because of infection and their support
for development of cancers, chronic infection and development of
therapeutic strategies for detection and control of the infection.
The field of microbiome research has exploded over the last five
years, and we are now understanding more and more about the context
in which microorganisms can contribute to the onset of cancers in
humans. The field of microbiome research has demonstrated that the
human body has specific biomes for tissues and that changes in
these biomes at the specific organ sites can result in disease.
These changes can result in dramatic differences in metabolic
shifts that, together with genetic mutations, will produce the
perfect niche for establishment of the particular infection
programmes in that organ site. We are just beginning to understand
what those changes are and how they influence the disease state.
Overall, we hope to bring together the varying degrees of
fluctuations in the microbiome at the major organ sites and how
these changes affect the normal cellular processes because of
dysregulation, leading to proliferation of the associated tissues.
The study of Burkitt's lymphoma is now in its 6 decade beginning
with its discovery by Dr. Dennis Burkitt in equatorial Africa in
the mid to late 1950's. A large body of information is available
which provides a current understanding of the underlying molecular
changes that are linked to the initiation and development of
Burkitt's lymphoma. This proposed volume will provide a
comprehensive view of Burkitt's Lymphoma from the diagnosis to
potential animal models for this disease and include a view from
physicians who have a up close view of the patients in populations
where the disease is rampant. We expect that this will be an
excellent resource for Medical students and faculty as well as
educated laypersons who have a person interest in the disease.
Future Directions in Infant Development Research bears wit- ness to
the significant shifts that have occurred in infancy research in
the recent past. While fundamental issues have tended to remain the
same, the emphasis and ways of address- ing these issues have
changed. This book is the first step toward a much richer and
fuller understanding of infant development.
The 2000 edition of this long running and highly respected series,
contains the best papers from the Ergonomics Society Annual
Conference in 2000. The individual papers provide insight into
current practice, presents new research findings, and forms an
invaluable reference source. In addition to mainstream ergonomists
and human factors specialists, Contemporary Ergonomics 2000 will
appeal to all those who have an interest in peoples' interaction
with their working and leisure environment - including designers,
manufacturing and production engineers, health and safety
specialists, occupational, applied and industrial psychologists and
applied physiologists.
The acknowledgment that viruses are potent biological factors in
driving many cancers have seen a dramatic upsurge in recent years
in large part to the success of the human papilloma virus vaccine
against invasive cervical carcinomas and followed by the awarding
of the noble prize in medicine in 2008 to Dr. Harald zurHausen who
identified the link between papilloma virus and cervical cancers.
Over the last few years there have been some volumes addressing
different aspects of viruses and cancers and to some extent
focusing on the DNA viruses, more specifically the human DNA
viruses. This proposed volume will attempt to review and address
the major gaps in current knowledge in DNA viruses as well as RNA
viruses bringing a historical perspective of where studies began to
a more recent molecular approach and vaccine successes in tumor
viruses. We will also cover other known oncogenic viruses
associated cancers in other mammals in addition to humans.
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