This book ventures into a new and exciting area of discovery that
directly ties our current knowledge of cancer to the discovery of
microorganisms associated with different types of cancers. Recent
studies demonstrate that microorganisms are directly linked to the
establishment of cancers and that they can also contribute to the
initiation, as well as persistence of, the cancers. Microbiome and
Cancer covers the current knowledge of microbiome and its
association with human cancers. It provides important reading for
novices, senior undergraduates in cancer and microbiology, graduate
students, junior investigators, residents, fellows and established
investigators in the fields of cancer and microbiology. We cover
areas related to known, broad concepts in microbiology and how they
can relate to the ongoing discoveries of the micro-environment and
the changes in the metabolic and physiologic states in that
micro-environment, which are important for the ongoing nurturing
and survival of the poly-microbial content that dictates activities
in that micro-environment. We cover the interactions of
microorganisms associated with gastric carcinomas, which are
important for driving this particular cancer. Additional areas
include oral cancers, skin cancers, ovarian cancers, breast
cancers, nasopharyngeal cancers, lung cancers, mesotheliomas,
Hodgkin's and non-Hodgkin's lymphomas, glioblastoma multiforme,
hepatocellular carcinomas, as well as the inflammatory response
related to the infectious agents in cancers. This book covers the
metabolic changes that occur because of infection and their support
for development of cancers, chronic infection and development of
therapeutic strategies for detection and control of the infection.
The field of microbiome research has exploded over the last five
years, and we are now understanding more and more about the context
in which microorganisms can contribute to the onset of cancers in
humans. The field of microbiome research has demonstrated that the
human body has specific biomes for tissues and that changes in
these biomes at the specific organ sites can result in disease.
These changes can result in dramatic differences in metabolic
shifts that, together with genetic mutations, will produce the
perfect niche for establishment of the particular infection
programmes in that organ site. We are just beginning to understand
what those changes are and how they influence the disease state.
Overall, we hope to bring together the varying degrees of
fluctuations in the microbiome at the major organ sites and how
these changes affect the normal cellular processes because of
dysregulation, leading to proliferation of the associated tissues.
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