The question that faces governments and militaries the world over is how best to allocate resources for management of defence in the new age. This book, by Shri A.K. Ghosh who has an economics background, explores the framework for change in resource allocation and capability building. It emphasises the importance of introducing programming in Indian defence to serve as a link between defence planning and budgeting. The mismatch between defence planning and budgeting needs to be connected by the introduction of resource constrained budgeting, having a multi-year perspective. The RMA, force modernisation, cost-benefit analysis, management of risks, and internal and external audits are among the many issues the author has provided a perspective on. It is argued by the author that defence needs to be viewed as a giant business and, where possible, business practices should be introduced. The book is recommended reading for the planners and decision-makers of defence management and will benefit readers from the armed forces as well. The lay readers interested in the subject of national defence and security will also find it useful and interesting.

In contrast to previous texts focusing on either computational, structural or synthetic methods, this one-of-a-kind guide integrates all three skill sets for a complete picture of contemporary structure-based design.
As a result, this practical book demonstrates how to develop a high-affinity ligand with drug-like properties for any given drug target for which a high-resolution structure exists. The authors, both of whom have successfully designed drug-like molecules that were later developed into marketed drugs, use numerous examples of recently developed drugs to present best practice in structure-based drug design with the novice in mind. By way of a carefully balanced mix of theoretical background and case studies from medicinal chemistry applications, readers will quickly and efficiently master the basic skills of successful drug design.

In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological functions, molecular structure and inhibition. Parts two to five present various case studies of successful protease inhibitor drug design and development, as well as current and potential uses of such inhibitors in pharmaceutical medicine, covering the major therapeutic targets HIV-1 protease, renin, beta-secretase, gamma-secretase, plasmepsins and fungal proteases.
A ready reference aimed primarily at professionals in the pharmaceutical industry, as well as for anyone studying proteases and their function.

The book includes a synthesis of research findings on the structure and evolution of the Central Indian Ocean Basin and its ferromanganese deposits, in particular, on the exploration campaign since 1980s. A comprehensive mixture of recent studies along with classical theories starting from the 1960s is the hallmark of the book. Recent concepts and hypotheses, and also critical appreciation of the state-of-the-art knowledge on nodule formation and resource management are incorporated.
After limiting the geographical extension of the nodule field and describing its physiographic, geological, biological, physical and chemical characteristics in chapter 1, the various structural, tectonic and volcanic elements are described in chapters 2 and 3. The bottom sediment characteristics that floor the nodules and crusts are dealt with in chapter 4. The nodules and crusts are described in detail in chapter 5, and their process of formation in the light of variable source material, local and regional tectonic activities, and midplate secondary volcanisms are discussed. The mining, environment, metallurgy, legal and economic aspects of the nodule resources are discussed in chapter 6. This title fulfils the growing need to bring voluminous, but scattered information in the form of a book for easy dissemination to students and researchers.
* First dedicated book on the Indian Ocean manganese nodule resources
* Comprehensively discusses the dynamics of nodule formation in the Indian Ocean Nodule Field (IONF)
* Independently assesses the influence of tectonics and volcanism on the manganese nodule resource potential in local and regional scales