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Patients who have problems in swallowing encounter difficulties in
taking tablets, particularly pediatric and geriatric patients. Such
problems can be resolved by means of orodispersible tablets. These
tablets disintegrate instantaneously when put on tongue, releasing
the drug that dissolves or disperses in the saliva.Metronidazole is
active against a wide variety of anaerobic protozoal parasites and
anaerobic bacteria.The present study aim to prepare tablets that
can rapidly disintegrate in oral cavity (orodispersible), another
challenge with this model drug is to mask the bitter taste. Taste
masking was achieved by using aminoalkyl methacrylate copolymer
(Eudragit E-100) in the different ratio (1:2 and 1:3) by extrusion
technique. The IR shows that there was no significant evidence for
interaction between drug and polymers. Six formulations were
prepared using taste masked granules and different disintegrants
(LH-11) and Avicel PH-102 by varying concentration.
The present investigation aimed at formulation, and evaluation of
vesicular drug carrier system liquid crystalline proliposomes for
transdermal delivery of antifungal agent, griseofulvin. Liquid
crystalline proliposomal gel (LCPG) formulations of griseofulvin
were prepared, and characterized for vesicles shape, size,
entrapment efficiency, and drug permeation across pig ear skin. The
effects of different formulation variables (type of alcohol, type
and concentration of surfactant) on transdermal permeability
profile were assessed. The optimized LCPG formulation showed
enhanced In Vitro skin permeation flux of 10.705 0.052 ug/cm2/hr as
compared to 0.028 0.02 ug/cm2/hr for plain drug solution in water.
Results indicated that the optimized proliposomal formulation of
griseofulvin had better skin permeation potential than plain drug
solution in water."
Tablets are solid unit dosage form of medicaments with or without
suitable diluents and prepared either by molding or compression.
They are solid, flat or biconvex disc in shape. They vary greatly
in shape, size and weight which depend upon amount of medicament
used and mode of administration. They also vary in hardness,
thickness, disintegration and dissolution characteristics and in
other aspects depending upon their intended use and method of
manufacture. Tablets are the most widely used solid dosage form of
medicament. Because of their advantages their popularity is
continuously increasing day by day. Hypertension is a very common
disorder, particularly past middle age. It is not a disease in
itself, but it is an important risk factor for cardiovascular
mortality and morbidity. The WHO-ISH guidelines defined it to 140
mm Hg systolic and 90 mm Hg diastolic, through risk appears to
increase even above 120/90 mm Hg.
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