This book constitutes the refereed proceedings of the 13th EAI International Conference on Practical Aspects of Digital Forensics and Cyber Crime, ICDF2C 2022, held in Boston, MA, during November 16-18, 2022. The 28 full papers included in this book were carefully reviewed and selected from 80 submissions. They were organized in topical sections as follows: Image Forensics; Forensics Analysis; spread spectrum analysis; traffic analysis and monitoring; malware analysis; security risk management; privacy and security.