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Metabolic Syndrome is an aggregation of conditions that together increases the risk of cardiovascular disease in individuals that would not otherwise be recognized to be at risk. Aim: to assess the status of high sensitive C reactive protein (hs-CRP) in patients with Metabolic Syndrome. METHODS: This study is a cross-sectional study. The patients included in this study were 48 patients (of both sexes) attending the Diabetic Consultant Clinic during the period from January, 2010 till the end of September, 2010. The study included another 50 apparently healthy volunteer that were comparable to patients group with respect to age and sex and serve as a control group. They were screened for Metabolic Syndrome criteria.For the two groups hs-CRP was measured using ELISA kit. The results: BMI and BP were significantly higher in the MetS than the control. MetS group had significantly higher (hs-CRP) levels than control group and significantly higher Lipid profile than the control group. In conclusion, high sensitive C Reactive Protein can thus be simple, powerful markers of Metabolic Syndrome.
This is a cross sectional study on 400 cases of diabetes mellitus who attended the National Diabetic centre/ AL-Mustensyria university for a period of 6 months. The main factor of metabolic syndrome was dysglycaemia followed by hypertension, obesity and dyslipidaemia. Females in this study were more prone to have metabolic syndrome; Male: Female ratio = 0.5. Those in the age group 60-69 have the highest frequency of metabolic syndrome. Those with BMI 30-40 have the highest frequency of metabolic syndrome. Conclusion: This study concludes that early diagnosis and aggressive treatment is needed for metabolic syndrome to avoid cardiovascular complications. This study is important because of its predictive power for cardiovascular complication and diabetes.
Preeclampsia is a form of high blood pressure manifested during pregnancy, it is a common major complication causing significant morbidity and mortality; however, its etiology is unknown. The systemic vasculature is a target tissue for sex steroid hormones. Estrogen, androgen, and progesterone all influence the function and pathophysiology of the systemic circulation by influencing endothelial derived nitric-oxide pathway. Evidence suggests that sex steroids also modulate electrolyte homeostasis, but data on cation pattern during pregnancy are conflicting. Moreover, the status of ionized calcium and magnesium during pregnancy and its complication preeclampsia, and its relation with endothelial derived nitric-oxide and sex hormones have not been described adequately. The aim of this study is to demonstrate the pattern of sex steroids, minerals and electrolytes during preeclampsia with respect to normal pregnancy, and the correlation of the above parameters with nitric-oxide pathway. This study shows thatpreeclamptics (in different gestational age groups) experience vasospasm, hyperandrogenemia, altered electrolytes and mineral status, with no difference in sex steroids.
In addition to hypercholesterolaemia and smoking, hypertension, a chronic disease with many cardiovascular complications, is one of the major risk factors for cardiac ischemia, and the main risk factor for cerebrovascular disease. To elucidate the role of oxidative stress and lipid peroxidation in hypertension and the effect of different medical therapies on these parameters.The present study included measurement of serum lipid profile, total lipid peroxidation and oxidized HDL ( Ox-HDL)in 69 patients aged 30-70 years . They were three groups according to the type of therapy: atenelol, captopril & no pharmacological antihypertensives NPAHT. The results were compared with those of 45 apparently healthy controls(age range=30-66 years). The results showed a significant elevation in serum MDA and the OX.non-HDL % with a significant reduction in the reduction in the OX.HDL % as compared to the controls. The disturbance in the oxidant / antioxidant balance happened despite the treatment and blood pressure control showing different pictures with different modalities of treatment, being the best with the captopril.
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