The progression of heart disease is associated with changes in the neurohumoral mechanisms that control cardiac function. The degree to which this neurohumoral remodelling occurs, even before overt signs of cardiac disease become manifest, is important for prognosis. To determine why some patients experience sudden death while others sustain life in the presence of severely compromised cardiac function, the neuronal control of cardiac electrical and mechanical events must be considered. Starting at the level of individual neurons and building upwards, this book describes the synergistic interactions that occur among intrathoracic and CNS feedback loops to permit precise control of regional cardiac behaviour. On this basic science foundation, subsequent clinical chapters explore the remodelling that occurs in this system with ageing, with the evolution of specific cardiac pathologies, and with the psychological concomitants of heart disease. Most importantly, these chapters provide unique insights into how specific therapies like beta-andrenergic receptor blockade not only affect cardiomyocytes directly but also mitigate the adverse neurohumoral changes that accompany disease processes, such as heart failure and essential hypertension. The paradigm advanced in this volume is that heart disease is a multifaceted phenomenon involving the interplay of neurohumoral, cardiomyocyte and structural elements, each of which depends on the other. With our cumulative understanding of these interdependent processes, new avenues for time-appropriate, targeted methods of treating heart diseases can be developed.

Cannes Prix du Jury-winning Scottish noir thriller about a Glasgow CCTV operator who ends up stalking a man she sees on screen. Andrea Arnold's first full-length feature after winning an Academy Award for her short film, 'Wasp', follows Jackie (Kate Dickie) a Glasgow CCTV control-room operator. One day, watching the monitors, she sees a man (Dickie Curran) she knows but is trying to forget and is soon helplessly outside her jurisdiction and brief, stalking the man, on camera, back to his flat. Eventually she crosses the line and goes to the address, meeting a young man (Martin Compston) whom, she finds out, lives there along with her subject.

Cannes Prix du Jury-winning Scottish noir thriller about a Glasgow CCTV operator who ends up stalking a man she sees on screen. Andrea Arnold's first full-length feature after winning an Academy Award for her short film, 'Wasp', follows Jackie (Kate Dickie) a Glasgow CCTV control-room operator. One day, watching the monitors, she sees a man (Dickie Curran) she knows but is trying to forget and is soon helplessly outside her jurisdiction and brief, stalking the man, on camera, back to his flat. Eventually she crosses the line and goes to the address, meeting a young man (Martin Compston) whom, she finds out, lives there along with her subject.