This book discusses the recent developments in the therapeutic implications of cancer stem cells for the effective diagnosis, prognosis, and treatment of cancer. It summarizes the various stem cells of common cancers including colon, pancreas, lungs, prostate, melanoma, and glioblastoma, and reviews the potential role of cancer stem cells in tissue aggressiveness, examining the functional contribution of cancer stem cells in the establishment and recurrence of cancerous tumors. Further, it explores the potential of cancer stem cells as novel therapeutic targets for the treatment and prevention of tumor progression. The book also discusses the various approaches for detecting, isolating, and characterizing different cancer stem cells and signaling pathways that control their replication, survival, and differentiation. Lastly, it explores the key features and mechanisms of drug resistance, chemo-resistance, and radio-resistance in cancer stem cells to improve therapeutic rationale.

This book illustrates the recent advancements in the role of functional foods in preventing age-related disorders. It correlates age-related diseases and the effect of dietary compounds from different functional foods, herbs, and nutraceuticals. Notably, the book describes unique nutrition problems in many chronic diseases such as bone disease, cardiovascular disorders, brain disorders, immune disorders, and cancers.  The book also discusses the use of functional foods for controlling osteoporosis, improving bone strength, maintaining dental health, controlling obesity, gut health, and maintaining immune function using functional ingredients such as probiotics and prebiotics. Further, it presents the state of the art of aging and nutrigenomics research and the molecular mechanisms underlying the beneficial effects of bioactive nutrients on major aging-related disorders. Finally, the book embodies the latest findings and the mechanisms of actions of functional foods in aging and degenerative diseases and their beneficial uses in the aged population. ​

This book discusses the recent developments in the therapeutic implications of cancer stem cells for the effective diagnosis, prognosis, and treatment of cancer. It summarizes the various stem cells of common cancers including colon, pancreas, lungs, prostate, melanoma, and glioblastoma, and reviews the potential role of cancer stem cells in tissue aggressiveness, examining the functional contribution of cancer stem cells in the establishment and recurrence of cancerous tumors. Further, it explores the potential of cancer stem cells as novel therapeutic targets for the treatment and prevention of tumor progression. The book also discusses the various approaches for detecting, isolating, and characterizing different cancer stem cells and signaling pathways that control their replication, survival, and differentiation. Lastly, it explores the key features and mechanisms of drug resistance, chemo-resistance, and radio-resistance in cancer stem cells to improve therapeutic rationale.

Cancer Stem Cells and Signaling Pathways explores the mechanism of cancer stem cell signaling pathways in cancer advancement, serving as an ideal reference guide for investigators with valuable answers to problems associated with anti-cancer treatments and an understanding of the crosstalk among the signaling pathways in CSC regulation. Despite recent advances in tumor therapy and a greater understanding of their biology, tumors continue to be a prevalent and fatal worldwide. According to a novel paradigm in tumor biology, a small percentage of the cells within a tumor known as cancer stem cells (CSCs) are predicted as a crucial population for tumor progression.

Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging.

Stem Cells and Signaling Pathways provides mechanistic insights into the role of stem cells to combat the COVID-19 outbreak and other pathologies where a cytokine storm is the cause of concern for e.g., radiation exposure, multiple organ failure and sepsis. The advent of SARS-CoV-2 resulted in a global pandemic, putting individuals with other comorbidities at a higher risk of infection. The whole world witnessed a massive shortage of medical and other essential supplies needed to combat the virus. That said, stem cell therapy has emerged as a potential treatment for viral diseases, including but not limited to COVID-19. Interestingly, the clinical trials in the patients having COVID-19 complications depicted faster recovery in patients post mesenchymal stem cells therapy owing to the decreased cytokines levels, anti-viral effects and regeneration of the infected tissue.