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This book discusses the recent developments in the therapeutic
implications of cancer stem cells for the effective diagnosis,
prognosis, and treatment of cancer. It summarizes the various stem
cells of common cancers including colon, pancreas, lungs, prostate,
melanoma, and glioblastoma, and reviews the potential role of
cancer stem cells in tissue aggressiveness, examining the
functional contribution of cancer stem cells in the establishment
and recurrence of cancerous tumors. Further, it explores the
potential of cancer stem cells as novel therapeutic targets for the
treatment and prevention of tumor progression. The book also
discusses the various approaches for detecting, isolating, and
characterizing different cancer stem cells and signaling pathways
that control their replication, survival, and differentiation.
Lastly, it explores the key features and mechanisms of drug
resistance, chemo-resistance, and radio-resistance in cancer stem
cells to improve therapeutic rationale.
This book discusses the recent developments in the therapeutic
implications of cancer stem cells for the effective diagnosis,
prognosis, and treatment of cancer. It summarizes the various stem
cells of common cancers including colon, pancreas, lungs, prostate,
melanoma, and glioblastoma, and reviews the potential role of
cancer stem cells in tissue aggressiveness, examining the
functional contribution of cancer stem cells in the establishment
and recurrence of cancerous tumors. Further, it explores the
potential of cancer stem cells as novel therapeutic targets for the
treatment and prevention of tumor progression. The book also
discusses the various approaches for detecting, isolating, and
characterizing different cancer stem cells and signaling pathways
that control their replication, survival, and differentiation.
Lastly, it explores the key features and mechanisms of drug
resistance, chemo-resistance, and radio-resistance in cancer stem
cells to improve therapeutic rationale.
Cancer Stem Cells and Signaling Pathways explores the mechanism of
cancer stem cell signaling pathways in cancer advancement, serving
as an ideal reference guide for investigators with valuable answers
to problems associated with anti-cancer treatments and an
understanding of the crosstalk among the signaling pathways in CSC
regulation. Despite recent advances in tumor therapy and a greater
understanding of their biology, tumors continue to be a prevalent
and fatal worldwide. According to a novel paradigm in tumor
biology, a small percentage of the cells within a tumor known as
cancer stem cells (CSCs) are predicted as a crucial population for
tumor progression.
This book illustrates the recent advancements in the role of
functional foods in preventing age-related disorders. It correlates
age-related diseases and the effect of dietary compounds from
different functional foods, herbs, and nutraceuticals. Notably, the
book describes unique nutrition problems in many chronic diseases
such as bone disease, cardiovascular disorders, brain disorders,
immune disorders, and cancers. The book also discusses the
use of functional foods for controlling osteoporosis, improving
bone strength, maintaining dental health, controlling obesity, gut
health, and maintaining immune function using functional
ingredients such as probiotics and prebiotics. Further, it presents
the state of the art of aging and nutrigenomics research and the
molecular mechanisms underlying the beneficial effects of bioactive
nutrients on major aging-related disorders. Finally, the book
embodies the latest findings and the mechanisms of actions of
functional foods in aging and degenerative diseases and their
beneficial uses in the aged population. ​
Stem Cells and Aging covers what is known about the effect of time
and age on the basic units of life, which are the corresponding
tissue-specific or adult stem cells. Even though the concept of
stem cells was introduced nearly a century ago by Alexander
Maximow, modern stem-cell research began in 1963 when James Till,
Ernest McCullough and Lou Siminovitch established assays to detect
hematopoietic stem cells. In fact, given the importance of the
aging-associated diseases, scientists have developed a keen
interest in understanding the aging process as they attempt to
define the role of dysfunctional stem cells in the aging process.
With an aging population worldwide, understanding these age-related
stem cell changes at a basic biology level and at the level of
their influences for regenerative medicine is of interest and
importance. There is increasing evidence that the aging process can
have much adverse effects on stem cells. In the modern era, one of
the emerging fields in treating human diseases is stem cell
research, as stem cells have the remarkable potential to treat a
wide range of diseases. Nevertheless, understanding the molecular
mechanism involved in aging and deterioration of stem cell function
is crucial in developing effective new therapies for aging.
This book compiles the theoritical studies done on cyclic peptidic
and peptidomimetic compounds.Ab initio 'Hartree Fock Molecuclar
Orbital' calculations have been done on cyclic compounds to
determine their potential to play role as ion and drug
carriers.Role of substituents and backbone type have been
thoroughly studied to understand properties which facilitate ion
selectivity and potential to cross Blood Brain Barrier.Lead
compound has been suggested to selectively remove zinc ions from
brain so as to reduce plaque formation responsible for Alzheimer's
disease.Also, a suitable carrier has been suggested for extensively
used drug, Levodopa used for treatment of patients suffering from
Parkinson's disease. The work with cyclic compounds is extended to
find out possibilities of self aggregation. Properties of cyclic
compounds to self aggregate/assemble lead to formation of hollow
tubular structures in nanorange.They also showed probability of
carrying drugs inside them in an efficient manner without forming
covalent bonds. This study reveals that cyclic compounds are very
interesting systems with wide variety of applications and can be
modified intelligently according to one's needs
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