The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1), which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities, which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross- tolerance in smokers and people treated with nicotine, disorders of the central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications.

The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross-tolerance in smokers and people treated with nicotine, disorders of central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications.

The dissipative nuclear reaction mechanism in low energy light heavy-ion collisions have been studied. Inclusive energy distributions for various fragments and light charged particles have been measured in a wide angular range in several reactions. In the 20Ne+12C reaction, the fragment yield was mostly from the equilibrium decay of composite system, although the cross-sections for B, C, N fragments were higher than the statistical model predictions. This enhancement in cross-section indicated the survival of orbiting-like phenomenon at the energy > 7 MeV/nucleon. The composite system is also deformed. In 20Ne+27Al reaction, both deep-inelastic and fusion-fission processes were found to contribute significantly to the fragment yield. The time scale for the deep-inelastic process was 10-22 seconds. It has been found that the extracted values of angular momentum dissipation were more than the corresponding phenomenological (sticking) limit predictions for light fragments. In addition, in- plane coincidence data gives information about the decay of the hot composite formed 20Ne+12C reaction at 158 MeV.