The HIV pandemic continues to levy a heavy burden on the human race world-wide. The estimated number of people who became newly infected with HIV in 2009 was 2.6 million; most of these individuals live in Sub-Saharan Africa, followed by India and Southeast Asia. An estimated 370,000 new cases of pediatric infections occurred globally in 2009 (or more than 1,000 new infections every day), practically all of them through mother-to-child transmission. Up to 40% of all new infant HIV infections occur during breastfeeding. While breastfeeding by HIV-infected mothers is not recommended in the U.S. and other resource-rich settings where safe replacement feeding is easily available, the situation is different in many resource-limited settings, where replacement feeding is not safe or available and carries a high risk of infections (diarrhea, pneumonia) and infant malnutrition. Mothers in such settings are faced with a difficult dilemma: to breastfeed their infants in order to provide their infants with its many benefits (nutritional, immunologic, cognitive), but to also risk transmitting HIV. These challenges have prompted an intensive search for new prophylactic and therapeutic strategies in order to prevent infants from acquiring HIV infection through breastfeeding. In this book, expert HIV researchers critically review every aspect of this highly evolving and topical subject. The opening chapters deal with the epidemiology, global magnitude and biologic mechanisms of HIV-1 transmission from mother to child through breastfeeding and include considerations of the virus (quantity, compartments, characteristics) and the host (genetic, immunity-innate, cellular, humoral). The effects of breastfeeding on the HIV-infected mother's health and nutritional status, and the social and cultural issues associated with the practice of breastfeeding are also discussed. The next few chapters provide cutting-edge reviews of the latest approaches to prevention of HIV transmission to the infant through breastfeeding, including antiretroviral strategies, nutritional and immune-based approaches, and treatment of expressed breast milk. The remaining chapters provide a fascinating review of the many iterations this subject has received, as reflected in the several different sets of guidelines for infant feeding by HIV-infected mothers issued by the World Health Organization, and a debate by leading scientists on whether HIV-infected mothers should breastfeed their infants-in resource-limited and in resource-rich settings. A comprehensive overview of the current state of implementing the new evidence for prevention of breastfeeding transmission of HIV all over the world is also presented. Essential reading for the many disciplines of scientists and clinicians working on HIV/AIDS and other retroviruses, pediatricians, obstetricians/gynecologists, as well as all health-care professionals interested in expanding their understanding on the subject.

The world is full of germs, and the news is full of stories about infectious diseases and antibiotic-resistant superbugs. What can parents do to protect their children? "Keeping Your Child Healthy in a Germ-Filled World" gives parents the information they need to shield their kids from infections and keep their family healthy.

Infections are harmful, but not all germs are bad. Dr. Athena P. Kourtis, a pediatrician and infectious disease specialist--and mother--teaches parents how to protect their kids without going overboard. She helps parents sort through the latest information about antibiotics, vaccines, hygiene, health foods, and home remedies, and she identifies which rules to follow--and which ones to ignore. She says:

- No to overprotecting your children from germs- No to antimicrobial soaps and cleaning products at home- No to over-prescribed antibiotics- Yes to strategic hand washing- Yes to being conscious of germs and the pathways they use- Yes to vaccines

She offers tips for protecting your children wherever they are--at home or school, on the playground, while traveling--and whatever they are doing--playing sports, camping, visiting the beach--and answers questions that commonly worry parents. How many times should you wash prewashed spinach? (At least twice.) Does getting enough sleep help fight infection? (Yes.) Are pre-sliced foods more likely to spread infection? (They are.)

Reading this comprehensive, illustrated guide is the first step to keeping your family healthy. Up-to-date, accurate information and a clear understanding of how germs and our bodies work will help you and your child stay afloat in the microbial sea.

This issue of Clinics in Perinatology, guest edited by Drs. Athena Kourtis and Marc Bulterys, examines Perinatal HIV/AIDS. Authorities in the field have come together to offer reviews on topics including Epidemiology of perinatal HIV infection: US and worldwide; Biology of perinatal HIV transmission: Timing, virologic and immunologic factors; Viral sequencing from HIV-infected mothers and infants: Molecular evolution, diversity, and risk factors for mother-to-child transmission; Diagnosis of perinatally-acquired HIV infection; Prevention of mother-to-child transmission of HIV: Antiretroviral strategies; Prevention of mother-to-child transmission of HIV: The role of Cesarean section; International recommendations for prevention of mother-to-child transmission of HIV; Immune-based approaches: active and passive immunization; Breastfeeding and HIV: Biology of transmission and current state-of-the-art regarding prevention; HIV drug resistance and mother-to-child transmission of HIV; Survival and health benefits of breastfeeding versus artificial feeding in infants of HIV-infected women: Developing vs. developed world; Clinical care of the HIV-exposed infant of HIV-infected mothers; Clinical care of the HIV-infected infants; Issues of prematurity and HIV exposure/infection; and Antiretroviral pharmacology: Special issues regarding pregnant women and neonates.

The world is full of germs, and the news is full of stories about infectious diseases and antibiotic-resistant superbugs. What can parents do to protect their children? "Keeping Your Child Healthy in a Germ-Filled World" gives parents the information they need to shield their kids from infections and keep their family healthy.

Infections are harmful, but not all germs are bad. Dr. Athena P. Kourtis, a pediatrician and infectious disease specialist--and mother--teaches parents how to protect their kids without going overboard. She helps parents sort through the latest information about antibiotics, vaccines, hygiene, health foods, and home remedies, and she identifies which rules to follow--and which ones to ignore. She says:

- No to overprotecting your children from germs- No to antimicrobial soaps and cleaning products at home- No to over-prescribed antibiotics- Yes to strategic hand washing- Yes to being conscious of germs and the pathways they use- Yes to vaccines

She offers tips for protecting your children wherever they are--at home or school, on the playground, while traveling--and whatever they are doing--playing sports, camping, visiting the beach--and answers questions that commonly worry parents. How many times should you wash prewashed spinach? (At least twice.) Does getting enough sleep help fight infection? (Yes.) Are pre-sliced foods more likely to spread infection? (They are.)

Reading this comprehensive, illustrated guide is the first step to keeping your family healthy. Up-to-date, accurate information and a clear understanding of how germs and our bodies work will help you and your child stay afloat in the microbial sea.

The HIV pandemic continues to levy a heavy burden on the human race world-wide. The estimated number of people who became newly infected with HIV in 2009 was 2.6 million; most of these individuals live in Sub-Saharan Africa, followed by India and Southeast Asia. An estimated 370,000 new cases of pediatric infections occurred globally in 2009 (or more than 1,000 new infections every day), practically all of them through mother-to-child transmission. Up to 40% of all new infant HIV infections occur during breastfeeding. While breastfeeding by HIV-infected mothers is not recommended in the U.S. and other resource-rich settings where safe replacement feeding is easily available, the situation is different in many resource-limited settings, where replacement feeding is not safe or available and carries a high risk of infections (diarrhea, pneumonia) and infant malnutrition. Mothers in such settings are faced with a difficult dilemma: to breastfeed their infants in order to provide their infants with its many benefits (nutritional, immunologic, cognitive), but to also risk transmitting HIV. These challenges have prompted an intensive search for new prophylactic and therapeutic strategies in order to prevent infants from acquiring HIV infection through breastfeeding. In this book, expert HIV researchers critically review every aspect of this highly evolving and topical subject. The opening chapters deal with the epidemiology, global magnitude and biologic mechanisms of HIV-1 transmission from mother to child through breastfeeding and include considerations of the virus (quantity, compartments, characteristics) and the host (genetic, immunity-innate, cellular, humoral). The effects of breastfeeding on the HIV-infected mother's health and nutritional status, and the social and cultural issues associated with the practice of breastfeeding are also discussed. The next few chapters provide cutting-edge reviews of the latest approaches to prevention of HIV transmission to the infant through breastfeeding, including antiretroviral strategies, nutritional and immune-based approaches, and treatment of expressed breast milk. The remaining chapters provide a fascinating review of the many iterations this subject has received, as reflected in the several different sets of guidelines for infant feeding by HIV-infected mothers issued by the World Health Organization, and a debate by leading scientists on whether HIV-infected mothers should breastfeed their infants-in resource-limited and in resource-rich settings. A comprehensive overview of the current state of implementing the new evidence for prevention of breastfeeding transmission of HIV all over the world is also presented. Essential reading for the many disciplines of scientists and clinicians working on HIV/AIDS and other retroviruses, pediatricians, obstetricians/gynecologists, as well as all health-care professionals interested in expanding their understanding on the subject.