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The four synthetic compounds named Ortho-amino aniline, 2-bromo
propyl amine hydrobromide, 3-bromopopyl ammonium bromide and
Benzimidazole-2-thiol were evaluated for their pharmacological
activity. Evaluation of anti-oxidant activity was done by DPPH free
radical scavenging activity. In this investigation, the compound
ortho amino aniline showed the highest free radical scavenging
activity with IC50 value 0.85 g/ml. At the same time
Benzimadazole-2-Thiol also showed strong antioxidant potential
having IC50 value 4.18 g/ml. The cyto-toxic activity was evaluated
using Brine shrimp lethality bio-assay. Among the supplied
compounds only ortho amino aniline and bennzimidazole-2-thiol
showed mild cyto-toxic activity compared to the positive standard
Vincristine sulfate. The analgesic activity was evaluated using
acetic acid induced writhing method. The compounds
Benzimidazole-2-thiol and 3-bromopopyl ammonium bromide at a dose
of 50 mg/kg showed significant analgesic activity with 37.85% and
42.85% inhibition of writhing. 3-bromopopyl ammonium bromide and
Benzimidazole-2-thiol showed mild hypnotic activity. None of the
compounds exhibited anti-microbial or ani-pyretic activity."
The crude methanolic extract and different fractions of plant
Boerhavia repens were subjected to a number of biological tests for
the evaluation of their pharmacological activity.The whole plant of
Boerhavia repens was extracted with methanol by cold extraction
method. The concentrated extract of the plant were then partitioned
into pet ether, carbon tetrachloride, dichloromethane and ethyl
acetate soluble fractions.The carbon tetrachloride, dichloromethane
and the ethyl acetate soluble fractions of the plant showed strong
anti-oxidant activity. The cytotoxicity evaluation of the plant
extracts were carried out by Brine Shrimp Lethality Bioassay. The
pet ether soluble fractions of the plant showed strong cytotoxic
activity. The crude methanolic extract and pet ether soluble
fraction at doses of 400 mg/kg exhibited strong analgesic activity,
anti-inflammatory and anti-pyretic activity. The different
fractions and the crude methanolic extract were also subjected to
anti-microbial assay. However no fractions exhibited strong
anti-microbial activity.
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