This book is the first to provide both a broad overview of the current methodologies being applied to drug design and in-depth analyses of progress in specific fields. It details state-of-the-art approaches to pharmaceutical development currently used by some of the world's foremost laboratories. The book features contributors from a variety of fields, new techniques, previously unpublished data, and extensive reference lists.

This book serves as an up-to-date Rorschach primer and elaborates on the various applications of Rorschach assessment for adolescents with respect to differential diagnosis, forensic consultation, and therapeutic assessment. It opens with three chapters that provide readers with a basic overview and introduction to the topics integrated throughout the text. The first reviews the development and foundations of the Rorschach Inkblot Method; the second discusses key issues in the assessment of adolescents, with particular attention to differentiating patterns of psychopathology from normal developmental variations; and the third presents general considerations in using performance-based assessment instruments in the assessment of personality functioning in adolescence. Later chapters explore the current status of the Rorschach Inkblot Method with respect to theoretical formulations, research findings, and practice guidelines. The final chapter draws on information in the preceding chapters to present a model for Rorschach assessment of adolescents. This model is designed to facilitate accurate and useful formulations of personality functioning that contribute substantially to advancing responsible adolescent development.

Psychodiagnosis in Schizophrenia is a reprint of a classic volume in assessment psychology that first appeared in 1966. The book concerns the use of psychodiagnostic techniques in the differential diagnosis of schizophrenia. The author first presents a conceptual analysis of schizophrenic disturbance in terms of impaired ego functioning and extrapolates from schizophrenic ego impairments to psychodiagnostic indices that have been demonstrated to assess them. In particular, Weiner refers to the Wechsler Adult Intelligence Scale, the Rorschach Inkblot Method, and the Draw-A-Person test. Clinical and research data delineating the nature of psychological deficits in schizophrenia are reviewed, and practical guidelines for the clinical assessment of these deficits are presented. The author next considers several differential diagnostic possibilities frequently considered in the evaluation of schizophrenic persons, with separate chapters devoted to the many forms of schizophrenia, such as: acute, chronic, paranoid, nonparanoid, incipient, remitting, borderline and pseudoneurotic. There are also chapters that focus on schizoaffective disorder and adolescent schizophrenia. The conceptual and empirical contributions to these distinctions are reviewed; accordingly, the differentiating characteristics of these subcategories are related to parameters of psychodiagnostic test performance. In additon, the process of differential psychodiagnosis in schizophrenia is illustrated by detailed case studies. In an extended new preface, the author comments on current perspectives and contemporary literature related to the individual chapters of the text.

Psychodiagnosis in Schizophrenia is a reprint of a classic volume in assessment psychology that first appeared in 1966. The book concerns the use of psychodiagnostic techniques in the differential diagnosis of schizophrenia. The author first presents a conceptual analysis of schizophrenic disturbance in terms of impaired ego functioning and extrapolates from schizophrenic ego impairments to psychodiagnostic indices that have been demonstrated to assess them. In particular, Weiner refers to the Wechsler Adult Intelligence Scale, the Rorschach Inkblot Method, and the Draw-A-Person test. Clinical and research data delineating the nature of psychological deficits in schizophrenia are reviewed, and practical guidelines for the clinical assessment of these deficits are presented.
The author next considers several differential diagnostic possibilities frequently considered in the evaluation of schizophrenic persons, with separate chapters devoted to the many forms of schizophrenia, such as: acute, chronic, paranoid, nonparanoid, incipient, remitting, borderline and pseudoneurotic. There are also chapters that focus on schizoaffective disorder and adolescent schizophrenia. The conceptual and empirical contributions to these distinctions are reviewed; accordingly, the differentiating characteristics of these subcategories are related to parameters of psychodiagnostic test performance. In additon, the process of differential psychodiagnosis in schizophrenia is illustrated by detailed case studies. In an extended new preface, the author comments on current perspectives and contemporary literature related to the individual chapters of the text.

This book is the first to provide both a broad overview of the current methodologies being applied to drug design and in-depth analyses of progress in specific fields. It details state-of-the-art approaches to pharmaceutical development currently used by some of the world's foremost laboratories. The book features contributors from a variety of fields, new techniques, previously unpublished data, and extensive reference lists.

This book exploits an understanding of disease pathogenesis by applying a variety of biological agents to therapy. It provides a broad overview of the current methodologies being applied to biological approaches to rational drug design and in depth analyses of progress in this specific field.

Inaugurates a series for scientists and clinicians on the application of recent biotechnological methods in experimental and clinical medicine. Focuses on the design, synthesis, and utilization of biologically active peptides (short strings of amino acids not large enough to warrant the term protein

Investigation into basic and advanced peptide design, synthesis, evaluation and utilization. New therapeutic approaches from experimental systems.

Genetic / DNA immunization represents a novel approach to vaccine and immune therapeutic development. The direct injec tion of nucleic acid expression cassettes into a living host results in a limited number of its cells becoming factories for production of the introduced gene products. This host-inappropriate gene expression has important immunological consequences, resulting in the specific immune activation of the host against the gene delivered antigen. The recent demonstration by a number of laboratories that the induced immune responses are functional in experimental models against both specific infectious diseases and cancers is likely to have dramatic consequences for the develop ment of a new generation of experimental vaccines and immune therapies. This technology has the potential to enable the pro duction of vaccines and immune-based therapies that are not only effective immunologically but are accessible to the entire world (rather than just to the most developed nations). Vaccine Development Vaccination against pathogenic microorganisms represents one of the most important advances in the history of medicine. Vaccines, including those against polio, measles, mumps, rubella, hepatitis A, hepatitis B, pertussis and other diseases, have dramatically improved and protected more human lives than any other avenue of modern medicine. The vaccine against smallpox, for example, has been so successful that it is now widely believed that this malicious killer, responsible for more deaths in the twentieth century than World Wars I and II combined, has been removed from the face of the earth.

This collection of essays by historians, historians of science and medicine, and literary and textual scholars--from the United States, Canada, Mexico, and Spain--analyzes the achievements of Dr. Francisco Hernandez (1515-87) in the history of medicine and science in Europe and the Americas. Celebrated in his own day as one of Spain's leading physicians and naturalists, he is now best remembered for his monumental work on the native plants and materia medica of central Mexico.
Sent to New Spain in 1570 by King Philip II to research and describe the natural history of the region, to assess the medical usefulness of the natural resources, and to gather ethnographic materials for an anthropological history, Hernandez was the first trained scientist to undertake scientific work in the New World. For seven years he gathered information throughout the Valley of Mexico, learning Nahuatl, recording local medical customs, studying indigenous medicines, and writing down all his observations. The result was "The Natural History of New Spain," written in Latin, which consisted of six folio volumes filled with descriptions of over 3,000 plants previously unknown in Europe (along with descriptions of a much smaller number of animals and minerals) and ten folio volumes of paintings by Mexican artists illustrating the plants and animals he described.
Hernandez died before he could publish his "Natural History," and the materials were placed in the Escorial, where they were extensively consulted, copied, abstracted, and translated by generations of scientists, medical specialists, and natural philosophers before they were destroyed by fire in 1671. Hernandez's work was still regarded as authoritative on a number of New World botanical topics as late as the nineteenth century, and his writings remain in use in popular form in Mexico today.
The sixteen essays in this volume treat the most important aspects of Hernandez's experience, including his education, his heterodox beliefs, and the state of medicine in both Spain and New Spain during his era. Other essays show the dissemination of the knowledge Hernandez accumulated, including his contributions to European botany and materia medica, his relationship to Spanish Baroque painting, the "globalization" of his work in the eighteenth century, and his place in nineteenth-century debates among Spanish scientists.

This second edition of Irving Weiner's classic comprehensive, clinician-friendly guide to utilizing the Rorschach for personality description has been revised to reflect both recent modifications in the Rorschach Comprehensive System and new evidence concerning the soundness and utility of Rorschach assessment. It integrates the basic ingredients of structural, thematic, behavioral, and sequence analysis strategies into systematic guidelines for describing personality functioning. It is divided into three parts. Part I concerns basic considerations in Rorschach testing and deals with conceptual and empirical foundations of the inkblot method and with critical issues in formulating and justifying Rorschach inferences. Part II is concerned with elements of interpretation that contribute to thorough utilization of data in a Rorschach protocol: the Comprehensive System search strategy; the complementary roles of projection and card pull in determining response characteristics; and the interpretive significance of structural variables, content themes, test behaviors, and the sequence in which various response characteristics occur. Each of the chapters presents and illustrates detailed guidelines for translating Rorschach findings into descriptions of structural and dynamic aspects of personality functioning. The discussion throughout emphasizes the implications of Rorschach data for personality assets and liabilities, with specific respect to adaptive and maladaptive features of the manner in which people attend to their experience, use ideation, modulate affect, manage stress, view themselves, and relate to others. Part III presents 10 case illustrations of how the interpretive principles delineated in Part II can be used to identify assets and liabilities in personality functioning and apply this information in clinical practice. These cases represent persons from diverse demographic backgrounds and demonstrate a broad range of personality styles and clinical issues. Discussion of these cases touches on numerous critical concerns in arriving at different diagnoses, formulating treatment plans, and elucidating structural and dynamic determinants of behavior.

This book serves as an up-to-date Rorschach primer and elaborates on the various applications of Rorschach assessment for adolescents with respect to differential diagnosis, forensic consultation, and therapeutic assessment. It opens with three chapters that provide readers with a basic overview and introduction to the topics integrated throughout the text. The first reviews the development and foundations of the Rorschach Inkblot Method; the second discusses key issues in the assessment of adolescents, with particular attention to differentiating patterns of psychopathology from normal developmental variations; and the third presents general considerations in using performance-based assessment instruments in the assessment of personality functioning in adolescence. Later chapters explore the current status of the Rorschach Inkblot Method with respect to theoretical formulations, research findings, and practice guidelines. The final chapter draws on information in the preceding chapters to present a model for Rorschach assessment of adolescents. This model is designed to facilitate accurate and useful formulations of personality functioning that contribute substantially to advancing responsible adolescent development.

This second edition of Irving Weiner's classic comprehensive, clinician-friendly guide to utilizing the Rorschach for personality description has been revised to reflect both recent modifications in the Rorschach Comprehensive System and new evidence concerning the soundness and utility of Rorschach assessment. It integrates the basic ingredients of structural, thematic, behavioral, and sequence analysis strategies into systematic guidelines for describing personality functioning. It is divided into three parts. Part I concerns basic considerations in Rorschach testing and deals with conceptual and empirical foundations of the inkblot method and with critical issues in formulating and justifying Rorschach inferences. Part II is concerned with elements of interpretation that contribute to thorough utilization of data in a Rorschach protocol: the Comprehensive System search strategy; the complementary roles of projection and card pull in determining response characteristics; and the interpretive significance of structural variables, content themes, test behaviors, and the sequence in which various response characteristics occur. Each of the chapters presents and illustrates detailed guidelines for translating Rorschach findings into descriptions of structural and dynamic aspects of personality functioning. The discussion throughout emphasizes the implications of Rorschach data for personality assets and liabilities, with specific respect to adaptive and maladaptive features of the manner in which people attend to their experience, use ideation, modulate affect, manage stress, view themselves, and relate to others. Part III presents 10 case illustrations of how the interpretive principles delineated in Part II can be used to identify assets and liabilities in personality functioning and apply this information in clinical practice. These cases represent persons from diverse demographic backgrounds and demonstrate a broad range of personality styles and clinical issues. Discussion of these cases touches on numerous critical concerns in arriving at different diagnoses, formulating treatment plans, and elucidating structural and dynamic determinants of behavior.

Volume 1 of 2. Coleridge's nephew, son-in-law, and first editor, Henry Nelson Coleridge, began at the end of 1822 a record of Coleridge's remarks as a way of preparing an anthology of the interests and thought of the great poet and critic. His manuscripts, gathered to form the major text of his new edition, include passages on relatives, friends, and various censorable topics omitted from the Table Talk of 1835 and unpublished until now. These two volumes also contain talk recorded by other listeners from 1798 until Coleridge's death in 1834. Some of these records have not been previously published; some are published from manuscripts that differ from versions previously known. Also included are previously unpublished remarks by Wordsworth. Along with a bibliography of earlier editions of Table Talk and other useful appendixes, Carl Woodring's edition reprints the second edition (1836), which differs from the manuscripts more extensively than the edition of 1835. THis is the first fully annotated edition of a work that long remained more popular in the United Kingdom than any of the works in prose published by Coleridge himself. The two volumes make a convenient encyclopedia of his ideas and interests. Carl Woodring is George Edward Woodberry Professor of Literature Emeritus at Columbia University. Originally published in 1990. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

In The Citizen-Patient in Revolutionary and Imperial Paris, Dora B. Weiner examines the experiences of the sick and handicapped indigent men, women, and children in Paris during the French Revolution and Empire. Weiner argues that significant groups of Revolutionary physicians and reformers interpreted equality to include every citizen's right to health care. These reformers faced political, religious, and professional opposition, and daunting problems of funding. And they needed the participation of the poor as "citizen-patients, " patients with both rights and duties, who acted as responsible partners in the pursuit and maintenance of public and personal health.

Weiner surveys the 20,000 patients institutionalized in twenty Paris hospitals and hospices and explains how the Revolution changed the status and work of nurses, pharmacists, midwives, and students, as well as doctors. Clinical teaching, professional specialization, and approaches to public health were all affected. Weiner emphasizes health care for children, deaf and blind people, and mentally ill patients and underscores the role of women as administrators and dispensers of hospital care.

Volume 1 of 2. Coleridge's nephew, son-in-law, and first editor, Henry Nelson Coleridge, began at the end of 1822 a record of Coleridge's remarks as a way of preparing an anthology of the interests and thought of the great poet and critic. His manuscripts, gathered to form the major text of his new edition, include passages on relatives, friends, and various censorable topics omitted from the Table Talk of 1835 and unpublished until now. These two volumes also contain talk recorded by other listeners from 1798 until Coleridge's death in 1834. Some of these records have not been previously published; some are published from manuscripts that differ from versions previously known. Also included are previously unpublished remarks by Wordsworth. Along with a bibliography of earlier editions of Table Talk and other useful appendixes, Carl Woodring's edition reprints the second edition (1836), which differs from the manuscripts more extensively than the edition of 1835. THis is the first fully annotated edition of a work that long remained more popular in the United Kingdom than any of the works in prose published by Coleridge himself. The two volumes make a convenient encyclopedia of his ideas and interests. Carl Woodring is George Edward Woodberry Professor of Literature Emeritus at Columbia University. Originally published in 1990. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Blogging has become a "must" for many independent and fee-only financial advisors. It's a great way to build your business by connecting with current and potential clients as well as referral sources. Blogging attracts prospects to your website, media attention, and speaking engagements. It also cements your reputation as a leader in your field. Savvy investment managers, wealth managers, and other financial professionals know blogs are an excellent way to communicate topical information before it gets stale. This deepens your relationships with current clients. But many advisors struggle to create a steady flow of compelling blog posts. This isn't surprising. After all, your professional training focused on helping clients manage their investments or finances. You may have never taken a writing class or written for publication. Don't worry Help has arrived. This book will help you conquer the challenge of producing high quality blog posts by following a step-by-step process, including how to: Generate and refine ideas for blog posts that will engage your readers Organize your thoughts before you write so you can write more quickly and effectively Edit your writing so it's reader-friendly and appealing Spread the word about your blog and attract more visitors

"Inalienable Possessions" tests anthropology's traditional assumptions about kinship, economics, power, and gender in an exciting challenge to accepted theories of reciprocity and marriage exchange. Focusing on Oceania societies from Polynesia to Papua New Guinea and including Australian Aborigine groups, Annette Weiner investigates the category of possessions that must "not" be given or, if they are circulated, must return finally to the giver. Reciprocity, she says, is only the superficial aspect of exchange, which overlays much more politically powerful strategies of keeping-while-giving.The idea of keeping-while-giving places women at the heart of the political process, however much that process may vary in different societies, for women possess a wealth of their own that gives them power. Power is intimately involved in cultural reproduction, and Weiner describes the location of power in each society, showing how the degree of control over the production and distribution of cloth wealth coincides with women's rank and the development of hierarchy in the community. Other inalienable possessions, whether material objects, landed property, ancestral myths, or sacred knowledge, bestow social identity and rank as well. Calling attention to their presence in Western history, Weiner points out that her formulations are not limited to Oceania. The paradox of keeping-while-giving is a concept certain to influence future developments in ethnography and the theoretical study of gender and exchange.