This Handbook brings together a collection of leading international authors to reflect on the influence of central contributions, or classics, that have shaped the development of the field of public policy and administration. The Handbook reflects on a wide range of key contributions to the field, selected on the basis of their international and wider disciplinary impact. Focusing on classics that contributed significantly to the field over the second half of the 20th century, it offers insights into works that have explored aspects of the policy process, of particular features of bureaucracy, and of administrative and policy reforms. Each classic is discussed by a leading international scholars. They offer unique insights into the ways in which individual classics have been received in scholarly debates and disciplines, how classics have shaped evolving research agendas, and how the individual classics continue to shape contemporary scholarly debates. In doing so, this volume offers a novel approach towards considering the various central contributions to the field. The Handbook offers students of public policy and administration state-of-the-art insights into the enduring impact of key contributions to the field.

This book describes the application of piezoelectric materials, particularly piezoceramics, in the wide field of actuators and sensors. It gives a step-by-step introduction to the structure and mechanics of piezoelectric beam bending actuators in multilayer technology, which are of increasing importance for industrial applications. The book presents the suitability of the developed theoretical aspects in a memorable way.

The aim of this book is to explore the challenges facing rural communities and economies and to demonstrate the potential of spatial microsimulation for policy and analysis in a rural context. This is done by providing a comprehensive overview of a particular spatial microsimulation model called SMILE (Simulation Model of the Irish Local Economy). The model has been developed over a ten year period for applied policy analyis in Ireland which is seen as an ideal study area given its large percentage of population living in rural areas. The book reviews the policy context and the state of the art in spatial microsimulation against which SMILE was developed, describes in detail its model design and calibration, and presents example of outputs showing what new information the model provides using a spatial matching process. The second part of the book explores a series of rural issues or problems, including the impacts of new or changing government or EU policies, and examines the contribution that spatial microsimulation can provide in each area.

This volume compiles information from physics, metallurgy, and mechanical and electrical engineering to epitomize the fundamental characteristics of flat rolling steel. Flat Rolling Fundamentals is drawn from in-depth analyses of metal properties and behaviors to technologies in application. The book provides a full characterization of steel, including structure, chemical composition, classifications, physical properties, deformation, and plasticity. The authors present different types of rolling mills and the defining physical analytical parameters.They also discuss the effects of hot rolling on steel and the role of lubrication and thermomechanical treatments to minimize these effects. This book presents qualitative and quantitative advances in cost-effective steel production.

Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases - and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume II extends into the role of phosphoinositides in membrane organization and vesicular traffic. Endocytosis and exocytosis are modulated by phosphoinositides, which determine the fate and activity of integral membrane proteins. Phosphatidylinositol(4,5)-bisphosphate is a prominent flag in the plasma membrane, while phosphatidylinositol-3-phosphate decorates early endosomes. The Golgi apparatus is rich in phosphatidylinositol-4-phosphate, stressed cells increase phosphatidylinositol(3,5)-bisphosphate, and the nucleus has a phosphoinositide metabolism of its own. Phosphoinositide-dependent signaling cascades and the spatial organization of distinct phosphoinositide species are required in organelle function, fission and fusion, membrane channel regulation, cytoskeletal rearrangements, adhesion processes, and thus orchestrate complex cellular responses including growth, proliferation, differentiation, cell motility, and cell polarization.

Over the course of the past two decades, horror cinema around the globe has become increasingly preoccupied with the concept of loss. Grief in Contemporary Horror Cinema: Screening Loss examines the theme of grief as it represented both indie and mainstream films, including works such as Jennifer Kent's watershed film The Babadook, Juan Antonio Bayona's award-sweeping El orfanato, Ari Aster's genre-straddling Midsommar, and Lars von Trier's visually stunning Melancholia. Analyzing depictions of grief ranging from the intimate grief of a small family to the collective grief of an entire nation, the essays illustrate how these works serve to provide unity, catharsis, and-sometimes-healing.

Post-suburbia is a term that encapsulates a variety of contemporary urban forms, in particular the 'edge city' - a term used to describe the rapid growth of new urban centres at the edges of established major cities. Widely discussed in the US, very little has been written about European edge cities and this book provides a comparative analysis of examples in Greece, Spain, Paris, Finland and the UK, offering a theoretical analysis of the edge city and of post-suburban Europe.

Paperback edition – coming March 2024. Hardback edition is available to pre-order now! The first novel in the sensational The Sequin Mysteries series, from world-renowned dancer and Strictly head judge Shirley Ballas. Behind the sequins and sparkle of Blackpool Tower Ballroom’s famous Dance Festival, the competition is about to turn deadly… When a promising young dancer collapses during the opening tango of the festival, Lily Richmond, dance legend, teacher and one-time world champion, is convinced that murder is afoot. There’s only one person who can help her delve into the mystery: her former student and private detective, Susie Cooper. But Susie vowed she’d never return to the ballroom – let alone go undercover as a professional dancer when there’s a killer on the loose… As the competition gets even fiercer and the bodies start to pile up, can the unlikely dance-detective duo unravel the rumours from the rumbas and expose the murderer’s identity, before they strike again?

Basic Biotechnique for Bioprocess and Bioentrepreneurship deals with the entire field of industrial biotechnology, starting from basic laboratory techniques, to scale-up, process development, demonstration and commercialization. The book compiles currently scattered materials on the topic and updates information based on practical experience and requirements.

The volume contains papers read at the International Conference of the ISDCL, held in Budapest in 2015. The contributors explore various aspects of worship as reflected in the literature of Judaism from the Second Temple period to Late Antiquity. The volume provides a fresh reading of various crucial issues especially within Old Testament Apocrypha and Pseudepigrapha, Rabbinic literature, Gnostic traditions, and the emerging synagogue. The papers analyse texts and artefacts that reveal how various groups of Judaism understood the concept of worship-a pre-eminent form of expressing religious identity and interpreting fundamental traditions.

The book investigates Ben Sira's attitudes toward all matters pertaining to sexuality in the context of family relations and gender issues. The author's seemingly negative attitude to women, the anxiety expressed in the discussions of marital and extramarital relations, and the disciplining of children can lead to the assumption that the work has a negative attitude toward sexuality. Ben Sira's book is a combination of carefully composed wisdom poems and of teachings on everyday issues, including marriage, family life, self-control, desires, and sexual promiscuity. The sage dedicates a greater number of passages than other wisdom books to the discussion of social relations especially in regard to family. In so doing his regular point of departure seems to be what benefits or damages these relations mean, and whether they bring disgrace to a person, especially through sexuality. In addition, we have to make a distinction between the attitudes of the writer of the original Hebrew text of the book and that of the Greek translator. The two texts, produced in different social settings, times and places, differ at times in regard to sexuality. This book examines the wisdom poems, some characterized by openness about issues of eroticism, and all sayings that concern matters pertaining to sexuality found in discussions of passions, family relations and gender issues, and warnings against sexual wrongdoing. All this is done with a special regard to the differences between the Hebrew original text and the Greek translation.

Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases - and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

Andric and his girlfriend Laura have been seeing each other for a long time now but it isn't clear what each sees in the other. Self-absorbed, delusional or just a regular couple? 'Big Love is primarily a critique of contemporary society, in which the triumph of liberal democracy has increased rather than diminished the Kafkaesque aspects of life.' - Charles Sabatos.

Haroun Soussan, narrator of Outcast and a Jewish convert to Islam, is a civil engineer and historian who's just completed his life's work, The Jews and History. The book opens with him getting an award from Saddam Hussein during the time of the Iran-Iraq war. Written in the form of an autobiography, the narrative moves in and out of the present, the recent, and more distant past, providing a unique and intimate chronicle of Iraq's contemporary political history. Shimon Ballas was born in Baghdad in 1930 and immigrated to Israel in 1951.

First published in 1983. Routledge is an imprint of Taylor & Francis, an informa company.

The Academy was a philosophical school established by Plato that safeguarded the continuity and the evolution of Platonism over a period of about 300 years. Its contribution to the development of Hellenistic philosophical and scientific thinking was decisive, but it also had a major impact on the formation of most of the other philosophical trends emerging during this period. This volume surveys the evidence for the historical and social setting in which the Academy operated, as well as the various shifts in the philosophical outlook of Platonism during its existence. Its contribution to the evolution of special sciences such as mathematics is also examined. The book further includes the first complete annotated translation in English of Philodemus' History of the Academy, preserved on a papyrus from Herculaneum. It thus offers a comprehensive picture of one of the most prominent and influential of all educational institutions in ancient Greece.

The Academy was a philosophical school established by Plato that safeguarded the continuity and the evolution of Platonism over a period of about 300 years. Its contribution to the development of Hellenistic philosophical and scientific thinking was decisive, but it also had a major impact on the formation of most of the other philosophical trends emerging during this period. This volume surveys the evidence for the historical and social setting in which the Academy operated, as well as the various shifts in the philosophical outlook of Platonism during its existence. Its contribution to the evolution of special sciences such as mathematics is also examined. The book further includes the first complete annotated translation in English of Philodemus' History of the Academy, preserved on a papyrus from Herculaneum. It thus offers a comprehensive picture of one of the most prominent and influential of all educational institutions in ancient Greece.

The aim of this book is to explore the challenges facing rural communities and economies and to demonstrate the potential of spatial microsimulation for policy and analysis in a rural context. This is done by providing a comprehensive overview of a particular spatial microsimulation model called SMILE (Simulation Model of the Irish Local Economy). The model has been developed over a ten year period for applied policy analyis in Ireland which is seen as an ideal study area given its large percentage of population living in rural areas. The book reviews the policy context and the state of the art in spatial microsimulation against which SMILE was developed, describes in detail its model design and calibration, and presents example of outputs showing what new information the model provides using a spatial matching process. The second part of the book explores a series of rural issues or problems, including the impacts of new or changing government or EU policies, and examines the contribution that spatial microsimulation can provide in each area.

Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases - and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume II extends into the role of phosphoinositides in membrane organization and vesicular traffic. Endocytosis and exocytosis are modulated by phosphoinositides, which determine the fate and activity of integral membrane proteins. Phosphatidylinositol(4,5)-bisphosphate is a prominent flag in the plasma membrane, while phosphatidylinositol-3-phosphate decorates early endosomes. The Golgi apparatus is rich in phosphatidylinositol-4-phosphate, stressed cells increase phosphatidylinositol(3,5)-bisphosphate, and the nucleus has a phosphoinositide metabolism of its own. Phosphoinositide-dependent signaling cascades and the spatial organization of distinct phosphoinositide species are required in organelle function, fission and fusion, membrane channel regulation, cytoskeletal rearrangements, adhesion processes, and thus orchestrate complex cellular responses including growth, proliferation, differentiation, cell motility, and cell polarization.

Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases - and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

This book examining diagnosis was first published in 1985. Diagnosis is at the centre of medical practice and depends on skilled information processing and decision making. Medical students, who will spend their working lives gathering information from patients, making decisions and solving problems need to be taught the necessary techniques. One aim of the book is, therefore, to give teachers an account of some of the basic ideas which have been applied to the diagnostic process and to medical problem solving in general. Another aim is to make teachers more aware of the principles underlying their clinical work, for it has been shown repeatedly that clinicians' actions do not always coincide with their teaching and there is a distinct gap between what they do and what they teach. This introduction to the fundamental concepts of information processing and decision making is written at a level which makes it appropriate reading for those who have not previously read widely in these areas. It will be of interest to clinical teachers in medical and allied health professions.

This book describes the application of piezoelectric materials, particularly piezoceramics, in the wide field of actuators and sensors. It gives a step-by-step introduction to the structure and mechanics of piezoelectric beam bending actuators in multilayer technology, which are of increasing importance for industrial applications. The book presents the suitability of the developed theoretical aspects in a memorable way.