Phosphoinositides I: Enzymes of Synthesis and Degradation (Paperback, 2012 ed.)

Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases - and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

General

Imprint:	Springer
Country of origin:	Netherlands
Series:	Subcellular Biochemistry, 58
Release date:	April 2014
First published:	2012
Editors:	Tamas Balla • Matthias Wymann • John D. York
Dimensions:	235 x 155 x 20mm (L x W x T)
Format:	Paperback
Pages:	356
Edition:	2012 ed.
ISBN-13:	978-9401781572
Categories:	Books > Science & Mathematics > Biology, life sciences > Biochemistry > Lipids Books > Science & Mathematics > Biology, life sciences > Biochemistry > Enzymology Books > Science & Mathematics > Biology, life sciences > Cellular biology > General Promotions
LSN:	9401781575
Barcode:	9789401781572

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